Severe Molecular Defects Exhibited by the R179H Mutation in Human Vascular Smooth Muscle &#945;-Actin.

Lu, Hailong; Fagnant, Patricia M; Krementsova, Elena B; Trybus, Kathleen M

Severe Molecular Defects Exhibited by the R179H Mutation in Human Vascular Smooth Muscle α-Actin.

Lu, Hailong; Fagnant, Patricia M; Krementsova, Elena B; Trybus, Kathleen M.

Afiliación

Lu H; From the Department of Molecular Physiology and Biophysics and University of Vermont, Burlington, Vermont 05446.
Fagnant PM; From the Department of Molecular Physiology and Biophysics and University of Vermont, Burlington, Vermont 05446.
Krementsova EB; From the Department of Molecular Physiology and Biophysics and University of Vermont, Burlington, Vermont 05446.
Trybus KM; From the Department of Molecular Physiology and Biophysics and University of Vermont, Burlington, Vermont 05446 kathleen.trybus@uvm.edu.

J Biol Chem ; 291(41): 21729-21739, 2016 Oct 07.

Article en En | MEDLINE | ID: mdl-27551047

Asunto(s)

Actinas/química; Mutación Missense; Actinas/genética; Actinas/metabolismo; Sustitución de Aminoácidos; Animales; Humanos; Ratones; Relación Estructura-Actividad; Transactivadores/química; Transactivadores/genética; Transactivadores/metabolismo

Palabras clave

actin; cofilin; contractile protein; formin; myosin; profilin; vascular smooth muscle cells

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Actinas / Mutación Missense Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos

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