Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain.

Hall, Sara M; LeBaron, Lindsay; Ramos-Colon, Cyf; Qu, Chaoling; Xie, Jennifer Yanhua; Porreca, Frank; Lai, Josephine; Lee, Yeon Sun; Hruby, Victor J

Hall, Sara M; LeBaron, Lindsay; Ramos-Colon, Cyf; Qu, Chaoling; Xie, Jennifer Yanhua; Porreca, Frank; Lai, Josephine; Lee, Yeon Sun; Hruby, Victor J.

Afiliación

Hall SM; Department of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.
LeBaron L; Department of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.
Ramos-Colon C; Department of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.
Qu C; Department of Pharmacology, University of Arizona , Tucson, Arizona 85719, United States.
Xie JY; Department of Pharmacology, University of Arizona , Tucson, Arizona 85719, United States.
Porreca F; Department of Pharmacology, University of Arizona , Tucson, Arizona 85719, United States.
Lai J; Department of Pharmacology, University of Arizona , Tucson, Arizona 85719, United States.
Lee YS; Department of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.
Hruby VJ; Department of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.

ACS Chem Neurosci ; 7(12): 1746-1752, 2016 12 21.

Article en En | MEDLINE | ID: mdl-27619237

Asunto(s)

Analgésicos no Narcóticos/farmacología; Analgésicos no Narcóticos/farmacocinética; Neuralgia/tratamiento farmacológico; Neuralgia/metabolismo; Receptores de Bradiquinina/metabolismo; Analgésicos no Narcóticos/sangre; Analgésicos no Narcóticos/síntesis química; Animales; Encéfalo/efectos de los fármacos; Encéfalo/metabolismo; Modelos Animales de Enfermedad; Descubrimiento de Drogas; Estabilidad de Medicamentos; Dinorfinas/química; Humanos; Masculino; Unión Proteica; Ratas Sprague-Dawley

Palabras clave

Antihyperalgesic effect; Bradykinin receptors; Neuropathic pain; Non-opioid dynorphin A; Peptide stability; Structure−activity relationship

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Bradiquinina / Analgésicos no Narcóticos / Neuralgia Límite: Animals / Humans / Male Idioma: En Revista: ACS Chem Neurosci Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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