Cytotoxic Naphthoquinone and Azaanthraquinone Derivatives from an Endophytic Fusarium solani.
J Nat Prod
; 80(4): 1173-1177, 2017 04 28.
Article
en En
| MEDLINE
| ID: mdl-28257197
ABSTRACT
Bioactivity-guided fractionation of the ethyl acetate extract obtained from the culture of the endophytic fungus Fusarium solani resulted in the isolation of one new naphthoquinone, 9-desmethylherbarine (1), and two azaanthraquinone derivatives, 7-desmethylscorpinone (2) and 7-desmethyl-6-methylbostrycoidin (3), along with four known compounds. Their structures were elucidated by spectral analysis, as well as a direct comparison of spectral data with those of known compounds. Azaanthraquinones 2 and 3 showed cytotoxic activity against four human tumor cell lines, MDA MB 231, MIA PaCa2, HeLa, and NCI H1975. A molecular docking study suggested DNA interactions as the mode of action of these naphthoquinones and azaanthraquinones.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos Aza
/
Antraquinonas
/
Naftoquinonas
/
Fusarium
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
J Nat Prod
Año:
2017
Tipo del documento:
Article
País de afiliación:
Bangladesh