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Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model.
Chapeau, Emilie A; Gembarska, Agnieszka; Durand, Eric Y; Mandon, Emeline; Estadieu, Claire; Romanet, Vincent; Wiesmann, Marion; Tiedt, Ralph; Lehar, Joseph; de Weck, Antoine; Rad, Roland; Barys, Louise; Jeay, Sebastien; Ferretti, Stephane; Kauffmann, Audrey; Sutter, Esther; Grevot, Armelle; Moulin, Pierre; Murakami, Masato; Sellers, William R; Hofmann, Francesco; Jensen, Michael Rugaard.
Afiliación
  • Chapeau EA; Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland; emilie.chapeau@novartis.com.
  • Gembarska A; Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Durand EY; Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Mandon E; Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Estadieu C; Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Romanet V; Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Wiesmann M; Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Tiedt R; Oncology Translational Research, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Lehar J; Oncology Disease Area, Novartis Institutes for BioMedical Research, Cambridge, MA 02139.
  • de Weck A; Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Rad R; Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany.
  • Barys L; German Cancer Research Center (DKFZ) and German Cancer Consortium, 69120 Heidelberg, Germany.
  • Jeay S; Oncology Translational Research, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Ferretti S; Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Kauffmann A; Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Sutter E; Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Grevot A; Preclinical Safety, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Moulin P; Preclinical Safety, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Murakami M; Preclinical Safety, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Sellers WR; Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
  • Hofmann F; Oncology Disease Area, Novartis Institutes for BioMedical Research, Cambridge, MA 02139.
  • Jensen MR; Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.
Proc Natl Acad Sci U S A ; 114(12): 3151-3156, 2017 03 21.
Article en En | MEDLINE | ID: mdl-28265066
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Elementos Transponibles de ADN / Mutagénesis Insercional / Proteína p53 Supresora de Tumor / Resistencia a Antineoplásicos / Proteínas Proto-Oncogénicas c-mdm2 / Vectores Genéticos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Elementos Transponibles de ADN / Mutagénesis Insercional / Proteína p53 Supresora de Tumor / Resistencia a Antineoplásicos / Proteínas Proto-Oncogénicas c-mdm2 / Vectores Genéticos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos