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Human mass balance study and metabolite profiling of 14C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer.
van Andel, Lotte; Zhang, Z; Lu, S; Kansra, V; Agarwal, S; Hughes, L; Tibben, M M; Gebretensae, A; Lucas, L; Hillebrand, M J X; Rosing, H; Schellens, J H M; Beijnen, J H.
Afiliación
  • van Andel L; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek Hospital / The Netherlands Cancer Institute and MC Slotervaart, P.O. Box 90440, 1006 BK, Amsterdam, The Netherlands. l.v.andel@nki.nl.
  • Zhang Z; Tesaro Inc., Waltham, MA, USA.
  • Lu S; Tesaro Inc., Waltham, MA, USA.
  • Kansra V; Tesaro Inc., Waltham, MA, USA.
  • Agarwal S; Tesaro Inc., Waltham, MA, USA.
  • Hughes L; Tesaro Inc., Waltham, MA, USA.
  • Tibben MM; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek Hospital / The Netherlands Cancer Institute and MC Slotervaart, P.O. Box 90440, 1006 BK, Amsterdam, The Netherlands.
  • Gebretensae A; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek Hospital / The Netherlands Cancer Institute and MC Slotervaart, P.O. Box 90440, 1006 BK, Amsterdam, The Netherlands.
  • Lucas L; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek Hospital / The Netherlands Cancer Institute and MC Slotervaart, P.O. Box 90440, 1006 BK, Amsterdam, The Netherlands.
  • Hillebrand MJX; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek Hospital / The Netherlands Cancer Institute and MC Slotervaart, P.O. Box 90440, 1006 BK, Amsterdam, The Netherlands.
  • Rosing H; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek Hospital / The Netherlands Cancer Institute and MC Slotervaart, P.O. Box 90440, 1006 BK, Amsterdam, The Netherlands.
  • Schellens JHM; Division of Clinical Pharmacology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Beijnen JH; Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Invest New Drugs ; 35(6): 751-765, 2017 12.
Article en En | MEDLINE | ID: mdl-28303528
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Piperidinas / Neoplasias de la Mama / Radioisótopos de Carbono / Neoplasias Colorrectales / Poli(ADP-Ribosa) Polimerasas / Poli(ADP-Ribosa) Polimerasa-1 / Indazoles Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Invest New Drugs Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Piperidinas / Neoplasias de la Mama / Radioisótopos de Carbono / Neoplasias Colorrectales / Poli(ADP-Ribosa) Polimerasas / Poli(ADP-Ribosa) Polimerasa-1 / Indazoles Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Invest New Drugs Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos