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Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.
van Esbroeck, Annelot C M; Janssen, Antonius P A; Cognetta, Armand B; Ogasawara, Daisuke; Shpak, Guy; van der Kroeg, Mark; Kantae, Vasudev; Baggelaar, Marc P; de Vrij, Femke M S; Deng, Hui; Allarà, Marco; Fezza, Filomena; Lin, Zhanmin; van der Wel, Tom; Soethoudt, Marjolein; Mock, Elliot D; den Dulk, Hans; Baak, Ilse L; Florea, Bogdan I; Hendriks, Giel; De Petrocellis, Luciano; Overkleeft, Herman S; Hankemeier, Thomas; De Zeeuw, Chris I; Di Marzo, Vincenzo; Maccarrone, Mauro; Cravatt, Benjamin F; Kushner, Steven A; van der Stelt, Mario.
Afiliación
  • van Esbroeck ACM; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.
  • Janssen APA; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.
  • Cognetta AB; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Ogasawara D; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Shpak G; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands.
  • van der Kroeg M; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands.
  • Kantae V; Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.
  • Baggelaar MP; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.
  • de Vrij FMS; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands.
  • Deng H; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.
  • Allarà M; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche (CNR), Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Italy.
  • Fezza F; Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy.
  • Lin Z; Department of Neuroscience, Erasmus Medical Centre, 3000 CA, Rotterdam, Netherlands.
  • van der Wel T; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.
  • Soethoudt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.
  • Mock ED; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.
  • den Dulk H; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.
  • Baak IL; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.
  • Florea BI; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.
  • Hendriks G; Toxys B.V., Robert Boyleweg 4, 2333 CG, Leiden, Netherlands.
  • De Petrocellis L; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche (CNR), Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Italy.
  • Overkleeft HS; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.
  • Hankemeier T; Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.
  • De Zeeuw CI; Department of Neuroscience, Erasmus Medical Centre, 3000 CA, Rotterdam, Netherlands.
  • Di Marzo V; Netherlands Institute for Neuroscience, Royal Dutch Academy of Arts and Sciences, 1105 BA, Amsterdam, Netherlands.
  • Maccarrone M; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche (CNR), Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Italy.
  • Cravatt BF; European Centre for Brain Research-Institute for Research and Healthcare (IRCCS) Santa Lucia Foundation, Via del Fosso del Fiorano 65, 00143 Rome, Italy.
  • Kushner SA; Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy.
  • van der Stelt M; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Science ; 356(6342): 1084-1087, 2017 06 09.
Article en En | MEDLINE | ID: mdl-28596366
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Ansiolíticos / Óxidos N-Cíclicos / Amidohidrolasas / Analgésicos / Neuronas Límite: Humans Idioma: En Revista: Science Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Ansiolíticos / Óxidos N-Cíclicos / Amidohidrolasas / Analgésicos / Neuronas Límite: Humans Idioma: En Revista: Science Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos