Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human.

Hosogi, Jun; Ohashi, Rui; Maeda, Hiroshi; Tashiro, Satoshi; Fuse, Eiichi; Yamamoto, Yorihiro; Kuwabara, Takashi

Hosogi, Jun; Ohashi, Rui; Maeda, Hiroshi; Tashiro, Satoshi; Fuse, Eiichi; Yamamoto, Yorihiro; Kuwabara, Takashi.

Afiliación

Hosogi J; Translational Research Unit, Research and Development Division, Kyowa Hakko Kirin Co., Ltd., 1188 Shimotogari, Sunto-gun, Nagaizumi-cho, Shizuoka 411-8731, Japan. Electronic address: jun.hosogi@kyowa-kirin.co.jp.
Ohashi R; Translational Research Unit, Research and Development Division, Kyowa Hakko Kirin Co., Ltd., 1188 Shimotogari, Sunto-gun, Nagaizumi-cho, Shizuoka 411-8731, Japan.
Maeda H; Translational Research Unit, Research and Development Division, Kyowa Hakko Kirin Co., Ltd., 1188 Shimotogari, Sunto-gun, Nagaizumi-cho, Shizuoka 411-8731, Japan.
Tashiro S; Translational Research Unit, Research and Development Division, Kyowa Hakko Kirin Co., Ltd., 1188 Shimotogari, Sunto-gun, Nagaizumi-cho, Shizuoka 411-8731, Japan.
Fuse E; Translational Research Unit, Research and Development Division, Kyowa Hakko Kirin Co., Ltd., 1188 Shimotogari, Sunto-gun, Nagaizumi-cho, Shizuoka 411-8731, Japan.
Yamamoto Y; School of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1 Katakura-cho, Hachioji, Tokyo 192-0983, Japan.
Kuwabara T; Translational Research Unit, Research and Development Division, Kyowa Hakko Kirin Co., Ltd., 1188 Shimotogari, Sunto-gun, Nagaizumi-cho, Shizuoka 411-8731, Japan.

Drug Metab Pharmacokinet ; 32(5): 255-264, 2017 Oct.

Article en En | MEDLINE | ID: mdl-28751116

Asunto(s)

Aldehído Oxidasa/metabolismo; Iminas/metabolismo; Indazoles/química; Indazoles/metabolismo; Monoaminooxidasa/metabolismo; Piperazinas/química; Piperazinas/metabolismo; Animales; Sistema Enzimático del Citocromo P-450/química; Sistema Enzimático del Citocromo P-450/metabolismo; Perros; Hepatocitos/química; Hepatocitos/metabolismo; Humanos; Iminas/química; Iones/química; Iones/metabolismo; Macaca fascicularis; Microsomas Hepáticos/química; Microsomas Hepáticos/metabolismo; Mitocondrias/química; Mitocondrias/metabolismo; Monoaminooxidasa/química; Oxidación-Reducción; Piperazina; Ratas

Palabras clave

Aldehyde oxidase; Hepatocyte; Iminium ion; In vitro in vivo extrapolation; Liver microsomes; Metabolism; Monoamine oxidase B; Piperazine

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas / Aldehído Oxidasa / Iminas / Indazoles / Monoaminooxidasa Límite: Animals / Humans Idioma: En Revista: Drug Metab Pharmacokinet Asunto de la revista: FARMACOLOGIA / METABOLISMO Año: 2017 Tipo del documento: Article

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google