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Secretory phospholipase A2 responsive liposomes exhibit a potent anti-neoplastic effect in vitro, but induce unforeseen severe toxicity in vivo.
Østrem, Ragnhild Garborg; Parhamifar, Ladan; Pourhassan, Houman; Clergeaud, Gael; Nielsen, Ole Lerberg; Kjær, Andreas; Hansen, Anders Elias; Andresen, Thomas Lars.
Afiliación
  • Østrem RG; Technical University of Denmark, Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Produktionstorvet, 2800 Kgs. Lyngby, Denmark.
  • Parhamifar L; Technical University of Denmark, Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Produktionstorvet, 2800 Kgs. Lyngby, Denmark.
  • Pourhassan H; Technical University of Denmark, Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Produktionstorvet, 2800 Kgs. Lyngby, Denmark.
  • Clergeaud G; Technical University of Denmark, Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Produktionstorvet, 2800 Kgs. Lyngby, Denmark.
  • Nielsen OL; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 3, 1870 Frederiksberg C, Denmark.
  • Kjær A; Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
  • Hansen AE; Technical University of Denmark, Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Produktionstorvet, 2800 Kgs. Lyngby, Denmark; Cluster for Molecular Imaging, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmar
  • Andresen TL; Technical University of Denmark, Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Produktionstorvet, 2800 Kgs. Lyngby, Denmark. Electronic address: thomas.andresen@nanotech.dtu.dk.
J Control Release ; 262: 212-221, 2017 Sep 28.
Article en En | MEDLINE | ID: mdl-28754610
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organoplatinos / Colesterol / Fosfolipasas A2 / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organoplatinos / Colesterol / Fosfolipasas A2 / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Países Bajos