In vitro and in vivo evaluation of hypothermia on pharmacokinetics and pharmacodynamics of nimodipine in rabbits.

Fei, Yu-Xing; Zhang, Tian-Hong; Zhao, Jing; Ren, He; Du, Ya-Nan; Yu, Chun-Ling; Wang, Qiang; Li, Shu; Ren, Ting-Lin; Jian, Qiang; Fei, Shu-Yang; Zhang, Zhen-Qing; Zhang, Yi

In vitro and in vivo evaluation of hypothermia on pharmacokinetics and pharmacodynamics of nimodipine in rabbits.

Fei, Yu-Xing; Zhang, Tian-Hong; Zhao, Jing; Ren, He; Du, Ya-Nan; Yu, Chun-Ling; Wang, Qiang; Li, Shu; Ren, Ting-Lin; Jian, Qiang; Fei, Shu-Yang; Zhang, Zhen-Qing; Zhang, Yi.

Afiliación

Fei YX; 1 Department of Cardiology, Navy General Hospital of PLA, Beijing, PR China.
Zhang TH; 2 Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, PR China.
Zhao J; 3 Department of Pharmacy, Navy General Hospital of PLA, Beijing, PR China.
Ren H; 4 Department of Ultrasound, Navy General Hospital of PLA, Beijing, PR China.
Du YN; 5 Department of Neurosurgery, Navy General Hospital of PLA, Beijing, PR China.
Yu CL; 3 Department of Pharmacy, Navy General Hospital of PLA, Beijing, PR China.
Wang Q; 3 Department of Pharmacy, Navy General Hospital of PLA, Beijing, PR China.
Li S; 3 Department of Pharmacy, Navy General Hospital of PLA, Beijing, PR China.
Ren TL; 3 Department of Pharmacy, Navy General Hospital of PLA, Beijing, PR China.
Jian Q; 3 Department of Pharmacy, Navy General Hospital of PLA, Beijing, PR China.
Fei SY; 6 Grade 2013, Clinical Medical College, Capital Medical University, Beijing, PR China.
Zhang ZQ; 2 Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, PR China.
Zhang Y; 3 Department of Pharmacy, Navy General Hospital of PLA, Beijing, PR China.

J Int Med Res ; 46(1): 335-347, 2018 Jan.

Article en En | MEDLINE | ID: mdl-28851258

Asunto(s)

Antihipertensivos/farmacocinética; Hepatocitos/efectos de los fármacos; Hipotermia Inducida; Microsomas Hepáticos/efectos de los fármacos; Nimodipina/farmacocinética; Vasodilatadores/farmacocinética; Animales; Antihipertensivos/sangre; Antihipertensivos/farmacología; Proteínas Sanguíneas/metabolismo; Temperatura Corporal; Circulación Cerebrovascular/efectos de los fármacos; Sistema Enzimático del Citocromo P-450/metabolismo; Frecuencia Cardíaca/efectos de los fármacos; Hepatocitos/metabolismo; Inyecciones Intravenosas; Masculino; Microsomas Hepáticos/metabolismo; Nimodipina/sangre; Nimodipina/farmacología; Cultivo Primario de Células; Unión Proteica; Conejos; Ultrasonografía Doppler; Resistencia Vascular/efectos de los fármacos; Vasodilatadores/sangre; Vasodilatadores/farmacología

Palabras clave

Hypothermia; clearance; cytochrome P450; exposure; nimodipine; pharmacodynamics; pharmacokinetics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasodilatadores / Microsomas Hepáticos / Nimodipina / Hepatocitos / Hipotermia Inducida / Antihipertensivos Límite: Animals Idioma: En Revista: J Int Med Res Año: 2018 Tipo del documento: Article

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