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Dysregulation of methionine metabolism in multiple sclerosis.
Singhal, N K; Freeman, E; Arning, E; Wasek, B; Clements, R; Sheppard, C; Blake, P; Bottiglieri, T; McDonough, J.
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  • Singhal NK; Department of Biological Sciences and School of Biomedical Sciences, Kent State University, Kent, OH 44240, United States. Electronic address: nsingha1@kent.edu.
  • Freeman E; Department of Biological Sciences and School of Biomedical Sciences, Kent State University, Kent, OH 44240, United States.
  • Arning E; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research Institute, Dallas, TX 75226, United States.
  • Wasek B; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research Institute, Dallas, TX 75226, United States.
  • Clements R; Department of Biological Sciences and School of Biomedical Sciences, Kent State University, Kent, OH 44240, United States.
  • Sheppard C; Oak Clinic for Multiple Sclerosis, Uniontown, OH, 44685, United States.
  • Blake P; Oak Clinic for Multiple Sclerosis, Uniontown, OH, 44685, United States.
  • Bottiglieri T; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research Institute, Dallas, TX 75226, United States.
  • McDonough J; Department of Biological Sciences and School of Biomedical Sciences, Kent State University, Kent, OH 44240, United States.
Neurochem Int ; 112: 1-4, 2018 01.
Article en En | MEDLINE | ID: mdl-29080803
We report a significant reduction in plasma methionine concentrations in relapse remitting multiple sclerosis (MS) patients compared to controls. In vivo studies demonstrate that changes in peripheral methionine levels in mice can regulate histone H3 methylation and expression of DNA methyltransferase 3A (DNMT3A) centrally, in the cerebral cortex. Therefore, we propose that decreases in circulating methionine represent one of the earliest manifestations of dysregulated methionine metabolism in MS with potential impacts on both histone H3 and DNA methylation in the central nervous system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Cerebral / Esclerosis Múltiple Recurrente-Remitente / Metionina Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Neurochem Int Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Cerebral / Esclerosis Múltiple Recurrente-Remitente / Metionina Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Neurochem Int Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido