The Truncated Isoform of the Receptor Tyrosine Kinase ALK Generated by Alternative Transcription Initiation (ALK<sup>ATI</sup>) Induces Chromatin Structural Changes in the Nucleus in a Kinase Activity-Dependent Manner.

Takakura, Yuki; Yamaguchi, Noritaka; Honda, Takuya; Morii, Mariko; Yuki, Ryuzaburo; Nakayama, Yuji; Yamaguchi, Naoto

The Truncated Isoform of the Receptor Tyrosine Kinase ALK Generated by Alternative Transcription Initiation (ALK^ATI) Induces Chromatin Structural Changes in the Nucleus in a Kinase Activity-Dependent Manner.

Takakura, Yuki; Yamaguchi, Noritaka; Honda, Takuya; Morii, Mariko; Yuki, Ryuzaburo; Nakayama, Yuji; Yamaguchi, Naoto.

Afiliación

Takakura Y; Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University.
Yamaguchi N; Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University.
Honda T; Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University.
Morii M; Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University.
Yuki R; Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University.
Nakayama Y; Department of Biochemistry and Molecular Biology, Kyoto Pharmaceutical University.
Yamaguchi N; Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University.

Biol Pharm Bull ; 40(11): 1968-1975, 2017.

Article en En | MEDLINE | ID: mdl-29093346

Asunto(s)

Proteínas de Anclaje a la Quinasa A/metabolismo; Núcleo Celular/metabolismo; Heterocromatina/metabolismo; Proteínas Tirosina Quinasas Receptoras/metabolismo; Proteínas de Anclaje a la Quinasa A/genética; Empalme Alternativo; Quinasa de Linfoma Anaplásico; Núcleo Celular/genética; Células HeLa; Heterocromatina/genética; Histonas/metabolismo; Humanos; Intrones/genética; Isoenzimas/genética; Isoenzimas/metabolismo; Fosforilación; Dominios Proteicos/genética; Proteínas Tirosina Quinasas Receptoras/genética; Sitio de Iniciación de la Transcripción

Palabras clave

A-kinase anchoring protein 8; alternative transcription initiation; anaplastic lymphoma kinase; chromatin structural change; heterochromatinization; nuclear tyrosine kinase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Heterocromatina / Núcleo Celular / Proteínas Tirosina Quinasas Receptoras / Proteínas de Anclaje a la Quinasa A Límite: Humans Idioma: En Revista: Biol Pharm Bull Asunto de la revista: BIOQUIMICA / FARMACOLOGIA Año: 2017 Tipo del documento: Article

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