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Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).
Tully, David C; Rucker, Paul V; Chianelli, Donatella; Williams, Jennifer; Vidal, Agnès; Alper, Phil B; Mutnick, Daniel; Bursulaya, Badry; Schmeits, James; Wu, Xiangdong; Bao, Dingjiu; Zoll, Jocelyn; Kim, Young; Groessl, Todd; McNamara, Peter; Seidel, H Martin; Molteni, Valentina; Liu, Bo; Phimister, Andrew; Joseph, Sean B; Laffitte, Bryan.
Afiliación
  • Tully DC; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Rucker PV; Novartis Institutes for Biomedical Research , Emeryville, California 94608, United States.
  • Chianelli D; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Williams J; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Vidal A; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Alper PB; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Mutnick D; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Bursulaya B; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Schmeits J; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Wu X; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Bao D; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Zoll J; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Kim Y; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Groessl T; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • McNamara P; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Seidel HM; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Molteni V; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Liu B; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Phimister A; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
  • Joseph SB; Novartis Institutes for Biomedical Research , Emeryville, California 94608, United States.
  • Laffitte B; Genomics Institute of the Novartis Research Foundation , San Diego, California 92121, United States.
J Med Chem ; 60(24): 9960-9973, 2017 12 28.
Article en En | MEDLINE | ID: mdl-29148806
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colestasis / Receptores Citoplasmáticos y Nucleares / Benzotiazoles / Enfermedad del Hígado Graso no Alcohólico / Isoxazoles Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colestasis / Receptores Citoplasmáticos y Nucleares / Benzotiazoles / Enfermedad del Hígado Graso no Alcohólico / Isoxazoles Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos