Enhancing mitochondrial proteostasis reduces amyloid-ß proteotoxicity.

Sorrentino, Vincenzo; Romani, Mario; Mouchiroud, Laurent; Beck, John S; Zhang, Hongbo; D'Amico, Davide; Moullan, Norman; Potenza, Francesca; Schmid, Adrien W; Rietsch, Solène; Counts, Scott E; Auwerx, Johan

Sorrentino, Vincenzo; Romani, Mario; Mouchiroud, Laurent; Beck, John S; Zhang, Hongbo; D'Amico, Davide; Moullan, Norman; Potenza, Francesca; Schmid, Adrien W; Rietsch, Solène; Counts, Scott E; Auwerx, Johan.

Afiliación

Sorrentino V; Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Romani M; Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Mouchiroud L; Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Beck JS; Department of Translational Science and Molecular Medicine, Department of Family Medicine, Michigan State University, Grand Rapids, Michigan 49503, USA.
Zhang H; Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
D'Amico D; Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Moullan N; Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Potenza F; Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Schmid AW; Proteomics Core Facility, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Rietsch S; Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Counts SE; Department of Translational Science and Molecular Medicine, Department of Family Medicine, Michigan State University, Grand Rapids, Michigan 49503, USA.
Auwerx J; Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

Nature ; 552(7684): 187-193, 2017 12 14.

Article en En | MEDLINE | ID: mdl-29211722

Asunto(s)

Enfermedad de Alzheimer/metabolismo; Enfermedad de Alzheimer/patología; Péptidos beta-Amiloides/metabolismo; Péptidos beta-Amiloides/toxicidad; Homeostasis; Mitocondrias/metabolismo; Proteostasis; Enfermedad de Alzheimer/genética; Animales; Caenorhabditis elegans/genética; Modelos Animales de Enfermedad; Homeostasis/efectos de los fármacos; Humanos; Masculino; Memoria/fisiología; Ratones; Ratones Transgénicos; Mitocondrias/efectos de los fármacos; Mitocondrias/genética; Mitocondrias/patología; Mitofagia/efectos de los fármacos; Mitofagia/genética; NAD/metabolismo; Niacinamida/análogos & derivados; Niacinamida/farmacología; Fosforilación Oxidativa; Agregación Patológica de Proteínas/tratamiento farmacológico; Biosíntesis de Proteínas/efectos de los fármacos; Proteostasis/efectos de los fármacos; Compuestos de Piridinio; Respuesta de Proteína Desplegada/genética

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Enfermedad de Alzheimer / Proteostasis / Homeostasis / Mitocondrias Límite: Animals / Humans / Male Idioma: En Revista: Nature Año: 2017 Tipo del documento: Article País de afiliación: Suiza

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