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Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis.
Silva, Maria C; Davoli-Ferreira, Marcela; Medina, Tiago S; Sesti-Costa, Renata; Silva, Grace K; Lopes, Carla D; Cardozo, Lucas E; Gava, Fábio N; Lyroni, Konstantina; Dias, Fabrício C; Frade, Amanda F; Baron, Monique; Nakaya, Helder I; Figueiredo, Florêncio; Alves-Filho, José C; Cunha, Fernando Q; Tsatsanis, Christos; Chevillard, Christophe; Cunha-Neto, Edecio; Hirsch, Emilio; Silva, João S; Cunha, Thiago M.
Afiliación
  • Silva MC; Department of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo, Bandeirantes Avenue, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
  • Davoli-Ferreira M; Department of Biochemistry and Immunology, Fiocruz- Bi-Institutional Translational Medicine Plataform, Ribeirão Preto Medical School, University of Sao Paulo, Bandeirantes Avenue, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
  • Medina TS; Post Graduation Program in Biotechnology, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil.
  • Sesti-Costa R; Department of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo, Bandeirantes Avenue, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
  • Silva GK; Department of Biochemistry and Immunology, Fiocruz- Bi-Institutional Translational Medicine Plataform, Ribeirão Preto Medical School, University of Sao Paulo, Bandeirantes Avenue, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
  • Lopes CD; Department of Biochemistry and Immunology, Fiocruz- Bi-Institutional Translational Medicine Plataform, Ribeirão Preto Medical School, University of Sao Paulo, Bandeirantes Avenue, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
  • Cardozo LE; Department of Biochemistry and Immunology, Fiocruz- Bi-Institutional Translational Medicine Plataform, Ribeirão Preto Medical School, University of Sao Paulo, Bandeirantes Avenue, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
  • Gava FN; Department of Biochemistry and Immunology, Fiocruz- Bi-Institutional Translational Medicine Plataform, Ribeirão Preto Medical School, University of Sao Paulo, Bandeirantes Avenue, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
  • Lyroni K; Department of Biochemistry and Immunology, Fiocruz- Bi-Institutional Translational Medicine Plataform, Ribeirão Preto Medical School, University of Sao Paulo, Bandeirantes Avenue, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
  • Dias FC; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, 05508-900, Brazil.
  • Frade AF; Department of Physiology, Ribeirão Preto Medical School, University of Sao Paulo, Bandeirantes Avenue, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
  • Baron M; Laboratory of Clinical Chemistry, School of Medicine, University of Crete, 71003, Heraklion, Greece.
  • Nakaya HI; Department of Biochemistry and Immunology, Fiocruz- Bi-Institutional Translational Medicine Plataform, Ribeirão Preto Medical School, University of Sao Paulo, Bandeirantes Avenue, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
  • Figueiredo F; Laboratory of Immunology, Heart Institute (InCor), School of Medicine, University of São Paulo, São Paulo, SP, 05403-900, Brazil.
  • Alves-Filho JC; Department of Bioengineering, Brazil University, Rua Carolina da Fonseca, 234 (Campus II), Itaquera, São Paulo, SP, 08230-030, Brazil.
  • Cunha FQ; Laboratory of Immunology, Heart Institute (InCor), School of Medicine, University of São Paulo, São Paulo, SP, 05403-900, Brazil.
  • Tsatsanis C; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, 05508-900, Brazil.
  • Chevillard C; Laboratory of Pathology, School of Medicine, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasilia, DF, 70910-900, Brazil.
  • Cunha-Neto E; Department of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo, Bandeirantes Avenue, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
  • Hirsch E; Department of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo, Bandeirantes Avenue, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
  • Silva JS; Laboratory of Clinical Chemistry, School of Medicine, University of Crete, 71003, Heraklion, Greece.
  • Cunha TM; TAGC/INSERM U1090, Aix Marseille Université AMU, Parc Scientifique de Luminy case 928, 163 Avenue de Luminy, 13288, Marseille, Cedex 09, France.
Nat Commun ; 9(1): 1513, 2018 04 17.
Article en En | MEDLINE | ID: mdl-29666415
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trypanosoma cruzi / Transducción de Señal / Cardiomiopatía Chagásica / Fosfatidilinositol 3-Quinasa Clase Ib Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trypanosoma cruzi / Transducción de Señal / Cardiomiopatía Chagásica / Fosfatidilinositol 3-Quinasa Clase Ib Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido