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A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition.
Favalli, Nicholas; Biendl, Stefan; Hartmann, Marco; Piazzi, Jacopo; Sladojevich, Filippo; Gräslund, Susanne; Brown, Peter J; Näreoja, Katja; Schüler, Herwig; Scheuermann, Jörg; Franzini, Raphael; Neri, Dario.
Afiliación
  • Favalli N; Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
  • Biendl S; Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
  • Hartmann M; Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
  • Piazzi J; Philochem AG, Liebernstrasse 3, 8112, Otelfingen, Switzerland.
  • Sladojevich F; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La, Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Gräslund S; Structural Genomics Consortium (SGC), University of Toronto, Toronto, ON, M5G 1L7, Canada.
  • Brown PJ; Department of Structural Biology, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, Scheeles väg 2, 17177, Stockholm, Sweden.
  • Näreoja K; Structural Genomics Consortium (SGC), University of Toronto, Toronto, ON, M5G 1L7, Canada.
  • Schüler H; Department of Structural Biology, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, Scheeles väg 2, 17177, Stockholm, Sweden.
  • Scheuermann J; Department of Structural Biology, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, Scheeles väg 2, 17177, Stockholm, Sweden.
  • Franzini R; Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
  • Neri D; Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.
ChemMedChem ; 13(13): 1303-1307, 2018 07 06.
Article en En | MEDLINE | ID: mdl-29856130
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN / Tanquirasas / Bibliotecas de Moléculas Pequeñas / Anhidrasa Carbónica IX / Albúmina Sérica Humana / Antígenos de Neoplasias Límite: Humans Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN / Tanquirasas / Bibliotecas de Moléculas Pequeñas / Anhidrasa Carbónica IX / Albúmina Sérica Humana / Antígenos de Neoplasias Límite: Humans Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Alemania