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hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.
Segeritz, Charis-Patricia; Rashid, Sheikh Tamir; de Brito, Miguel Cardoso; Serra, Maria Paola; Ordonez, Adriana; Morell, Carola Maria; Kaserman, Joseph E; Madrigal, Pedro; Hannan, Nicholas R F; Gatto, Laurent; Tan, Lu; Wilson, Andrew A; Lilley, Kathryn; Marciniak, Stefan J; Gooptu, Bibek; Lomas, David A; Vallier, Ludovic.
Afiliación
  • Segeritz CP; Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, UK; Cambridge Institute for Medical Research, University of Cambridge, UK.
  • Rashid ST; Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, UK; Cambridge Institute for Medical Research, University of Cambridge, UK; Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King's College London, UK. Electronic ad
  • de Brito MC; Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, UK.
  • Serra MP; Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King's College London, UK.
  • Ordonez A; Cambridge Institute for Medical Research, University of Cambridge, UK.
  • Morell CM; Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, UK.
  • Kaserman JE; Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center, Boston, MA 02118, USA.
  • Madrigal P; Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, UK.
  • Hannan NRF; Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, UK.
  • Gatto L; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Building O, Downing Site, Cambridge CB2 1QW, UK.
  • Tan L; Cambridge Institute for Medical Research, University of Cambridge, UK.
  • Wilson AA; Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center, Boston, MA 02118, USA.
  • Lilley K; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Building O, Downing Site, Cambridge CB2 1QW, UK.
  • Marciniak SJ; Cambridge Institute for Medical Research, University of Cambridge, UK.
  • Gooptu B; NIHR Leicester BRC-Respiratory and Leicester Institute of Structural & Chemical Biology, University of Leicester, UK; ISMB/Birkbeck & UCL, University of London, UK; Division of Asthma, Allergy and Lung Biology, King's College London, UK.
  • Lomas DA; UCL Respiratory, University College London, UK. Electronic address: d.lomas@ucl.ac.uk.
  • Vallier L; Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, UK; Wellcome Trust Sanger Institute, Genome Campus Hinxton, UK. Electronic address: lv225@cam.ac.uk.
J Hepatol ; 69(4): 851-860, 2018 Oct.
Article en En | MEDLINE | ID: mdl-29879455
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de alfa 1-Antitripsina / Hepatocitos / Células Madre Pluripotentes Inducidas / Respuesta de Proteína Desplegada / Inflamación Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de alfa 1-Antitripsina / Hepatocitos / Células Madre Pluripotentes Inducidas / Respuesta de Proteína Desplegada / Inflamación Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Países Bajos