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Effect of probiotic interventions on depressive symptoms: A narrative review evaluating systematic reviews.
Nadeem, Ibrahim; Rahman, Mohammed Z; Ad-Dab'bagh, Yasser; Akhtar, Mahmood.
Afiliación
  • Nadeem I; Faculty of Bachelor of Health Sciences, McMaster University, Hamilton, Canada.
  • Rahman MZ; School of Medicine, The University of Queensland, Brisbane, Australia.
  • Ad-Dab'bagh Y; Mental Health Department, Neuroscience Center, King Fahad Specialist Hospital-Dammam, Dammam, Saudi Arabia.
  • Akhtar M; Department of Psychiatry, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Psychiatry Clin Neurosci ; 73(4): 154-162, 2019 Apr.
Article en En | MEDLINE | ID: mdl-30499231
ABSTRACT
Depression is one of the most prevalent mental illnesses and is often associated with various other medical disorders. Since the 1980s, the primary pharmacological treatment has been antidepressants, but due to the recent discovery of the association between the gut microbiome and mental health, probiotics have been proposed as an adjunctive or alternate treatment. In this narrative review, we aim to provide a holistic perspective by synthesizing and evaluating existing evidence, discussing key biological mechanisms, exploring the history of probiotic use, and appreciating the influence of modern diet on mental health. Five online databases were searched for relevant studies up to December 2017. Systematic reviews that included randomized controlled trials assessing the efficacy of probiotics in the treatment of depressive symptoms were included. Seven systematic reviews met the inclusion criteria. Three of these reviews conducted meta-analyses, out of which, two concluded that probiotics improved depressive symptoms in the sample population. Out of the four reviews that conducted qualitative analysis, three reviews concluded that probiotics have the potential to be used as a treatment. Due to the differences in clinical trials, a definitive effect of probiotics on depressive symptoms cannot be concluded. Nonetheless, probiotics seem to potentially produce a significant therapeutic effect for subjects with pre-existing depressive symptoms. Further studies are warranted for definitive conclusions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metaanálisis como Asunto / Probióticos / Depresión / Trastorno Depresivo / Revisiones Sistemáticas como Asunto Tipo de estudio: Clinical_trials / Diagnostic_studies / Qualitative_research / Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Canadá

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metaanálisis como Asunto / Probióticos / Depresión / Trastorno Depresivo / Revisiones Sistemáticas como Asunto Tipo de estudio: Clinical_trials / Diagnostic_studies / Qualitative_research / Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Canadá