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Notch1 provides myocardial protection by improving mitochondrial quality control.
Zhou, Xue-Liang; Wu, Xia; Xu, Qi-Rong; Zhu, Rong-Rong; Xu, Hua; Li, Yun-Yun; Liu, Sheng; Huang, Huang; Xu, Xinping; Wan, Li; Wu, Qi-Cai; Liu, Ji-Chun.
Afiliación
  • Zhou XL; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Wu X; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Xu QR; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Zhu RR; Department of Obstetrics and Gynecology, Jiangxi Province Hospital of Integrated Traditional Chinese and Western Medicine, Nanchang, China.
  • Xu H; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Li YY; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Liu S; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Huang H; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Xu X; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Wan L; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Wu QC; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
  • Liu JC; Department of Cardiac Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, China.
J Cell Physiol ; 234(7): 11835-11841, 2019 07.
Article en En | MEDLINE | ID: mdl-30515819
Mitochondrial quality control is a new target for myocardial protection. Notch signaling plays an important role in heart development, maturation, and repair. However, the role of Notch in the myocardial mitochondrial quality control remains elusive. In this study, we isolated myocardial cells from rats and established myocardial ischemia reperfusion injury (IRI) model. We modulated Notch1 expression level in myocardial cells via infection with recombinant adenoviruses Ad-N1ICD and Ad-shN1ICD. We found that IR reduced myocardial cells viability, but Notch1 overexpression increased the viability of myocardial cells exposed to IRI. In addition, Notch1 overexpression improved ATP production, increased mitochondrial fusion and decreased mitochondrial fission, and inhibited mitophagy in myocardial cells exposed to IRI. However, N1ICD knockdown led to opposite effects. The myocardial protection role of Notch1 was related to the inhibition of Pink1 expression and Mfn2 and Parkin phosphorylation. In conclusion, Notch1 exerts myocardial protection and this is correlated with the maintenance of mitochondrial quality control and the inhibition of Pink1/Mfn2/Parkin signaling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptor Notch1 / Mitocondrias Cardíacas / Miocardio Límite: Animals Idioma: En Revista: J Cell Physiol Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptor Notch1 / Mitocondrias Cardíacas / Miocardio Límite: Animals Idioma: En Revista: J Cell Physiol Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos