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Human iPSC-based model of severe congenital neutropenia reveals elevated UPR and DNA damage in CD34+ cells preceding leukemic transformation.
Dannenmann, Benjamin; Zahabi, Azadeh; Mir, Perihan; Oswald, Benedikt; Bernhard, Regine; Klimiankou, Maksim; Morishima, Tatsuya; Schulze-Osthoff, Klaus; Zeidler, Cornelia; Kanz, Lothar; Lachmann, Nico; Moritz, Thomas; Welte, Karl; Skokowa, Julia.
Afiliación
  • Dannenmann B; Department of Oncology, Hematology, Immunology, Rheumatology, and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany.
  • Zahabi A; Department of Oncology, Hematology, Immunology, Rheumatology, and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany.
  • Mir P; Department of Oncology, Hematology, Immunology, Rheumatology, and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Oswald B; Department of Oncology, Hematology, Immunology, Rheumatology, and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany.
  • Bernhard R; Department of Oncology, Hematology, Immunology, Rheumatology, and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany.
  • Klimiankou M; Department of Oncology, Hematology, Immunology, Rheumatology, and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany.
  • Morishima T; Department of Oncology, Hematology, Immunology, Rheumatology, and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany.
  • Schulze-Osthoff K; German Cancer Research Center (DKFZ), Heidelberg, Germany; Interfaculty Institute of Biochemistry, Tübingen University, Germany.
  • Zeidler C; Department of Hematology, Oncology, and Bone Marrow Transplantation, Hannover Medical School, Hannover, Germany.
  • Kanz L; Department of Oncology, Hematology, Immunology, Rheumatology, and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany.
  • Lachmann N; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
  • Moritz T; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
  • Welte K; University Children's Hospital Tuebingen, Tuebingen, Germany.
  • Skokowa J; Department of Oncology, Hematology, Immunology, Rheumatology, and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany. Electronic address: julia.skokowa@med.uni-tuebingen.de.
Exp Hematol ; 71: 51-60, 2019 03.
Article en En | MEDLINE | ID: mdl-30615903
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Leucemia / Transformación Celular Neoplásica / Células Madre Pluripotentes Inducidas / Respuesta de Proteína Desplegada / Modelos Biológicos / Neutropenia Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Exp Hematol Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Leucemia / Transformación Celular Neoplásica / Células Madre Pluripotentes Inducidas / Respuesta de Proteína Desplegada / Modelos Biológicos / Neutropenia Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Exp Hematol Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos