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Multi-Epitope Fusion Protein Eg mefAg-1 as a Serodiagnostic Candidate for Cystic Echinococcosis in Sheep.
Tianli, Liu; Xifeng, Wang; Zhenzhong, Tian; Lixia, Wang; Xingxing, Zhang; Jun, Qiao; Qingling, Meng; Shasha, Gong; Ying, Chen; Xuepeng, Cai.
Afiliación
  • Tianli L; College of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
  • Xifeng W; College of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
  • Zhenzhong T; College of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
  • Lixia W; College of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
  • Xingxing Z; State Key Laboratory for Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural and Reclamation Science, Shihezi, Xinjiang 832000, China.
  • Jun Q; College of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
  • Qingling M; College of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
  • Shasha G; College of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
  • Ying C; College of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
  • Xuepeng C; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China.
Korean J Parasitol ; 57(1): 61-67, 2019 Feb.
Article en En | MEDLINE | ID: mdl-30840802
Cystic echinococcosis (CE) in sheep is a hazardous zoonotic parasitic disease that is caused by Echinococcus granulosus (Eg). At present, serological test is an important diagnostic method for Eg infection in domestic animals. Here, a fusion protein Eg mefAg-1 harboring 8 dominant B-cell epitopes of Eg such as antigen B, tetraspanin 1, tetraspanin 6, reticulon and Eg95 was produced in E. coli and evaluated for CE in sheep by indirect ELISA. Eg mefAg-1 showed in ELISA a high sensitivity (93.41%) and specificity (99.31%), with a coincidence rate of 97.02%. Overall, it is suggested that the Eg mefAg-1 could be a potential antigen candidate for CE serodiagnosis in sheep.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de las Ovejas / Ensayo de Inmunoadsorción Enzimática / Pruebas Serológicas / Anticuerpos Antihelmínticos / Equinococosis / Echinococcus / Antígenos Helmínticos Tipo de estudio: Diagnostic_studies / Evaluation_studies / Incidence_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Korean J Parasitol Asunto de la revista: PARASITOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Corea del Sur
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de las Ovejas / Ensayo de Inmunoadsorción Enzimática / Pruebas Serológicas / Anticuerpos Antihelmínticos / Equinococosis / Echinococcus / Antígenos Helmínticos Tipo de estudio: Diagnostic_studies / Evaluation_studies / Incidence_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Korean J Parasitol Asunto de la revista: PARASITOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Corea del Sur