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Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Chalupova, Katarina; Korabecny, Jan; Bartolini, Manuela; Monti, Barbara; Lamba, Doriano; Caliandro, Rosanna; Pesaresi, Alessandro; Brazzolotto, Xavier; Gastellier, Anne-Julie; Nachon, Florian; Pejchal, Jaroslav; Jarosova, Michaela; Hepnarova, Vendula; Jun, Daniel; Hrabinova, Martina; Dolezal, Rafael; Zdarova Karasova, Jana; Mzik, Martin; Kristofikova, Zdena; Misik, Jan; Muckova, Lubica; Jost, Petr; Soukup, Ondrej; Benkova, Marketa; Setnicka, Vladimir; Habartova, Lucie; Chvojkova, Marketa; Kleteckova, Lenka; Vales, Karel; Mezeiova, Eva; Uliassi, Elisa; Valis, Martin; Nepovimova, Eugenie; Bolognesi, Maria Laura; Kuca, Kamil.
Afiliación
  • Chalupova K; National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic; Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic.
  • Korabecny J; National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 58
  • Bartolini M; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, I-40126, Bologna, Italy.
  • Monti B; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, I-40126, Bologna, Italy.
  • Lamba D; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Area Science Park - Basovizza, S.S. n° 14-Km 163.5, I-34149, Trieste, Italy.
  • Caliandro R; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Area Science Park - Basovizza, S.S. n° 14-Km 163.5, I-34149, Trieste, Italy.
  • Pesaresi A; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Area Science Park - Basovizza, S.S. n° 14-Km 163.5, I-34149, Trieste, Italy.
  • Brazzolotto X; Institut de Recherche Biomédicale des Armées, Département de Toxicologie et Risques Chimiques, 1 Place Général Valérie André, 91220, Brétigny-sur-Orge, France.
  • Gastellier AJ; Institut de Recherche Biomédicale des Armées, Département de Toxicologie et Risques Chimiques, 1 Place Général Valérie André, 91220, Brétigny-sur-Orge, France.
  • Nachon F; Institut de Recherche Biomédicale des Armées, Département de Toxicologie et Risques Chimiques, 1 Place Général Valérie André, 91220, Brétigny-sur-Orge, France.
  • Pejchal J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.
  • Jarosova M; Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05, Hradec Kralove, Czech Republic.
  • Hepnarova V; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
  • Jun D; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
  • Hrabinova M; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
  • Dolezal R; Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
  • Zdarova Karasova J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
  • Mzik M; Institute of Clinical Biochemistry and Diagnosis, University Hospital, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
  • Kristofikova Z; National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic.
  • Misik J; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
  • Muckova L; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.
  • Jost P; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
  • Soukup O; National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 58
  • Benkova M; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
  • Setnicka V; Department of Analytical Chemistry, University of Chemistry and Technology Prague, Technicka 5, 166 28, Prague, Czech Republic.
  • Habartova L; Department of Analytical Chemistry, University of Chemistry and Technology Prague, Technicka 5, 166 28, Prague, Czech Republic.
  • Chvojkova M; National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic; Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 142 20, Prague, Czech Republic.
  • Kleteckova L; National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic; Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 142 20, Prague, Czech Republic.
  • Vales K; National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic; Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 142 20, Prague, Czech Republic.
  • Mezeiova E; National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
  • Uliassi E; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, I-40126, Bologna, Italy.
  • Valis M; Department of Neurology, Charles University in Prague, Faculty of Medicine in Hradec Kralove and University Hospital, Simkova 870, 500 03, Hradec Kralove, Czech Republic.
  • Nepovimova E; Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic.
  • Bolognesi ML; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, I-40126, Bologna, Italy. Electronic address: marialaura.bolognesi@unibo.it.
  • Kuca K; Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic. Electronic address: kamil.kuca@fnhk.cz.
Eur J Med Chem ; 168: 491-514, 2019 Apr 15.
Article en En | MEDLINE | ID: mdl-30851693
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tacrina / Triptófano / Inhibidores de la Colinesterasa / Fármacos Neuroprotectores / Enfermedad de Alzheimer Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tacrina / Triptófano / Inhibidores de la Colinesterasa / Fármacos Neuroprotectores / Enfermedad de Alzheimer Límite: Animals / Humans / Male Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Francia