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Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.
Paudel, Prajwal; Zhang, Qi; Leung, Charles; Greenberg, Harrison C; Guo, Yusong; Chern, Yi-Hsuan; Dong, Aiping; Li, Yanjun; Vedadi, Masoud; Zhuang, Zhihao; Tong, Yufeng.
Afiliación
  • Paudel P; Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716.
  • Zhang Q; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Leung C; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Greenberg HC; Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716.
  • Guo Y; Fisheries College, Guangdong Ocean University, Zhanjiang, 524025 Guangdong, China.
  • Chern YH; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Dong A; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Li Y; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Vedadi M; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Zhuang Z; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Tong Y; Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716; zzhuang@udel.edu ytong@uwindsor.ca.
Proc Natl Acad Sci U S A ; 116(15): 7288-7297, 2019 04 09.
Article en En | MEDLINE | ID: mdl-30914461
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Modelos Moleculares / Poliubiquitina / Ubiquitina Tiolesterasa Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Modelos Moleculares / Poliubiquitina / Ubiquitina Tiolesterasa Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos