Sasanquasaponin &#921;&#921;&#921; from Schima crenata Korth induces autophagy through Akt/mTOR/p70S6K pathway and promotes apoptosis in human melanoma A375 cells.

Liang, Qiu-Ping; Xu, Tian-Qi; Liu, Bai-Lian; Lei, Xue-Ping; Hambrook, Jacob R; Zhang, Dong-Mei; Zhou, Guang-Xiong

Sasanquasaponin ΙΙΙ from Schima crenata Korth induces autophagy through Akt/mTOR/p70S6K pathway and promotes apoptosis in human melanoma A375 cells.

Liang, Qiu-Ping; Xu, Tian-Qi; Liu, Bai-Lian; Lei, Xue-Ping; Hambrook, Jacob R; Zhang, Dong-Mei; Zhou, Guang-Xiong.

Afiliación

Liang QP; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Product, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.
Xu TQ; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Product, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.
Liu BL; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Product, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.
Lei XP; College of Pharmacy, Guangzhou Medical University, Guangzhou, Guangdong 510632, China.
Hambrook JR; School of Public Health, University of Alberta, Edmonton, AB T6G2G7, Canada.
Zhang DM; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Product, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.
Zhou GX; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Product, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China. Electronic address: guangxzh@sina.com.

Phytomedicine ; 58: 152769, 2019 May.

Article en En | MEDLINE | ID: mdl-31005714

Asunto(s)

Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Autofagia/efectos de los fármacos; Melanoma/tratamiento farmacológico; Saponinas/farmacología; Theaceae/química; Antineoplásicos/química; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Humanos; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Proteínas Proto-Oncogénicas c-akt/genética; Proteínas Proto-Oncogénicas c-akt/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Proteínas Quinasas S6 Ribosómicas 70-kDa/genética; Proteínas Quinasas S6 Ribosómicas 70-kDa/metabolismo; Saponinas/química; Transducción de Señal/efectos de los fármacos; Serina-Treonina Quinasas TOR/genética; Serina-Treonina Quinasas TOR/metabolismo

Palabras clave

Akt/mTOR/p70S6K pathway; Apoptosis; Autophagy; ROS; Sasanquasaponin III

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saponinas / Autofagia / Apoptosis / Theaceae / Melanoma / Antineoplásicos Límite: Humans Idioma: En Revista: Phytomedicine Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania

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