Innate Immune Protein Tag7 Stimulates the Appearance of Cytotoxic NK Cells after Incubation with Lymphocytes.

Sharapova, T N; Romanova, E A; Sashchenko, L P; Gnuchev, N V; Yashin, D V

Sharapova, T N; Romanova, E A; Sashchenko, L P; Gnuchev, N V; Yashin, D V.

Afiliación

Sharapova TN; Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia. sharapovatat.nik@gmail.com.
Romanova EA; Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia.
Sashchenko LP; Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia.
Gnuchev NV; Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia.
Yashin DV; Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia.

Dokl Biochem Biophys ; 484(1): 92-94, 2019 May.

Article en En | MEDLINE | ID: mdl-31012024

RESUMEN

Tag7 (PGRP-S) is an innate immune protein that is involved in the antibacterial and antitumor defense and stimulates the maturation of cytotoxic lymphocyte subpopulations. It was found that the incubation of lymphocytes with Tag7 for 3 days promotes the appearance of cytotoxic NK cells that are active against a number of tumor cell lines.

Asunto(s)

Citocinas/inmunología; Inmunidad Celular; Células Asesinas Naturales/inmunología; Neoplasias/inmunología; Técnicas de Cocultivo; Humanos; Células K562; Células Asesinas Naturales/patología; Neoplasias/patología

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Citocinas / Inmunidad Celular / Neoplasias Límite: Humans Idioma: En Revista: Dokl Biochem Biophys Asunto de la revista: BIOFISICA / BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos

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