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Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan.
Salk, Jesse J; Loubet-Senear, Kaitlyn; Maritschnegg, Elisabeth; Valentine, Charles C; Williams, Lindsey N; Higgins, Jacob E; Horvat, Reinhard; Vanderstichele, Adriaan; Nachmanson, Daniela; Baker, Kathryn T; Emond, Mary J; Loter, Emily; Tretiakova, Maria; Soussi, Thierry; Loeb, Lawrence A; Zeillinger, Robert; Speiser, Paul; Risques, Rosa Ana.
Afiliación
  • Salk JJ; Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, WA 98195, USA; TwinStrand Biosciences, Seattle, WA 98121, USA.
  • Loubet-Senear K; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Maritschnegg E; Molecular Oncology Group, Department of Obstetrics and Gynecology, Comprehensive Cancer Center-Gynecologic Cancer Unit, Medical University of Vienna, Vienna, Austria.
  • Valentine CC; TwinStrand Biosciences, Seattle, WA 98121, USA.
  • Williams LN; TwinStrand Biosciences, Seattle, WA 98121, USA.
  • Higgins JE; TwinStrand Biosciences, Seattle, WA 98121, USA.
  • Horvat R; Department of Pathology, Medical University of Vienna, Vienna, Austria.
  • Vanderstichele A; Department of Gynecologic Oncology, Leuven Cancer Institute, University Hospitals Leuven, Katholieke Universiteit, Leuven, Belgium.
  • Nachmanson D; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Baker KT; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Emond MJ; Department of Statistics, University of Washington, Seattle, WA 98195, USA.
  • Loter E; Department of Pathology, Seattle Children's Hospital, Seattle, WA 98105, USA.
  • Tretiakova M; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Soussi T; Sorbonne Université, UPMC Université Paris 06, 75005 Paris, France; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; INSERM, U1138, Centre de Recherche des Cordeliers, Paris, France.
  • Loeb LA; Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  • Zeillinger R; Molecular Oncology Group, Department of Obstetrics and Gynecology, Comprehensive Cancer Center-Gynecologic Cancer Unit, Medical University of Vienna, Vienna, Austria.
  • Speiser P; Molecular Oncology Group, Department of Obstetrics and Gynecology, Comprehensive Cancer Center-Gynecologic Cancer Unit, Medical University of Vienna, Vienna, Austria.
  • Risques RA; Department of Pathology, University of Washington, Seattle, WA 98195, USA. Electronic address: rrisques@uw.edu.
Cell Rep ; 28(1): 132-144.e3, 2019 07 02.
Article en En | MEDLINE | ID: mdl-31269435
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Envejecimiento / ADN de Neoplasias / Proteína p53 Supresora de Tumor / Evolución Clonal Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged / Newborn Idioma: En Revista: Cell Rep Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Envejecimiento / ADN de Neoplasias / Proteína p53 Supresora de Tumor / Evolución Clonal Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged / Newborn Idioma: En Revista: Cell Rep Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos