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Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma.
Noel, Marcus; O'Reilly, Eileen M; Wolpin, Brian M; Ryan, David P; Bullock, Andrea J; Britten, Carolyn D; Linehan, David C; Belt, Brian A; Gamelin, Eric C; Ganguly, Bishu; Yin, Donghua; Joh, Tenshang; Jacobs, Ira A; Taylor, Carrie T; Lowery, Maeve A.
Afiliación
  • Noel M; Department of Medicine, Division of Hematology/Oncology, University of Rochester Medical Center School of Medicine & Dentistry, Rochester, NY, USA.
  • O'Reilly EM; Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA.
  • Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Ryan DP; MGH Cancer Center, Division of Hematogy-Oncology, Massachusetts General Hospital, Boston, MA, USA.
  • Bullock AJ; Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Britten CD; Division of Hematology/Oncology, Medical University of South Carolina, Charleston, SC, USA.
  • Linehan DC; Department of Surgery, University of Rochester Medical Center School of Medicine & Dentistry, Rochester, NY, USA.
  • Belt BA; Department of Surgery, University of Rochester, Rochester, NY, USA.
  • Gamelin EC; Early Oncology Development and Clinical Research, Pfizer Inc, 219 East 42nd Street, New York, NY, 10017, USA.
  • Ganguly B; Early Oncology Development and Clinical Research, Pfizer Inc, 219 East 42nd Street, New York, NY, 10017, USA.
  • Yin D; Lyell Immunopharma Inc, Palo Alto, CA, USA.
  • Joh T; Early Oncology Development and Clinical Research, Pfizer Inc, 219 East 42nd Street, New York, NY, 10017, USA.
  • Jacobs IA; Early Oncology Development and Clinical Research, Pfizer Inc, 219 East 42nd Street, New York, NY, 10017, USA.
  • Taylor CT; Early Oncology Development and Clinical Research, Pfizer Inc, 219 East 42nd Street, New York, NY, 10017, USA. ira.jacobs@pfizer.com.
  • Lowery MA; Early Oncology Development and Clinical Research, Pfizer Inc, 219 East 42nd Street, New York, NY, 10017, USA.
Invest New Drugs ; 38(3): 800-811, 2020 06.
Article en En | MEDLINE | ID: mdl-31297636
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Quimiocina CCL2 / Carcinoma Ductal Pancreático / Bibliotecas de Moléculas Pequeñas Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Invest New Drugs Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Quimiocina CCL2 / Carcinoma Ductal Pancreático / Bibliotecas de Moléculas Pequeñas Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Invest New Drugs Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos