Transplantation of autologous bone marrow-derived mesenchymal stem cells under arthroscopic surgery with microfracture versus microfracture alone for articular cartilage lesions in the knee: A multicenter prospective randomized control clinical trial.
Regen Ther
; 11: 106-113, 2019 Dec.
Article
en En
| MEDLINE
| ID: mdl-31312692
ABSTRACT
INTRODUCTION:
To investigate the efficacy of the transplantation of autologous bone marrow-derived mesenchymal stem cells (BMSCs) under arthroscopy with microfracture (MFX) compared with microfracture alone.METHODS:
Eleven patients with a symptomatic articular cartilage defect of the knee were included in the study. They were randomized to receive BMSCs with MFX (cell-T group, n=7) or MFX alone (control group, n=4). Clinical results were evaluated using International Knee Documentation committee (IKDC) knee evaluation questionnaires and the Knee Injury and Osteoarthritis Outcome Score (KOOS) before and 48 weeks after surgery. Quantitative and qualitative assessments of repair tissue were carried out at 48 weeks by T2 mapping of magnetic resonance images (MRIs) and the magnetic resonance observation of cartilage repair tissue (MOCART) scoring system with follow-up MRI.RESULTS:
No significant differences between preoperative and postoperative IKDC and KOOS were observed in the cell-T or control group. However, forty-eight weeks after surgery, the cell-T group showed a trend for a greater KOOS QOL score compared with the control group (79.4 vs. 39.1, respectively; P=0.07). The T2 value did not differ significantly between the two groups, but the mean MOCART score was significantly higher in the cell-T group than in the control group (P=0.02).CONCLUSIONS:
Compared with MFX alone, BMSC transplantation with MFX resulted in better postoperative healing of the cartilage and subchondral bone as determined by the MOCART score. Clinically, BMSC transplantation with MFX gave a higher KOOS QOL score after 48 weeks.
BMSCs, bone marrow-derived mesenchymal stem cells; Bone marrow-derived mesenchymal stem cells; CPC, cell processing centers; GFP, green fluorescent protein; HA, hyaluronic acid; IKDC, International Knee Documentation committee; KL, KellgrenLawrence; KOOS, Knee Injury and Osteoarthritis Outcome Score; MFX, microfracture; MOCART, magnetic resonance observation of cartilage repair tissue; MRIs, magnetic resonance images; Microfracture; Prospective randomized control clinical trial; QOL, quality of life; RCT, randomized controlled trial
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Clinical_trials
/
Qualitative_research
Aspecto:
Patient_preference
Idioma:
En
Revista:
Regen Ther
Año:
2019
Tipo del documento:
Article
País de afiliación:
Japón