Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes.

Sewanan, Lorenzo R; Schwan, Jonas; Kluger, Jonathan; Park, Jinkyu; Jacoby, Daniel L; Qyang, Yibing; Campbell, Stuart G

Sewanan, Lorenzo R; Schwan, Jonas; Kluger, Jonathan; Park, Jinkyu; Jacoby, Daniel L; Qyang, Yibing; Campbell, Stuart G.

Afiliación

Sewanan LR; Department of Biomedical Engineering, Yale University, New Haven, Connecticut.
Schwan J; Department of Biomedical Engineering, Yale University, New Haven, Connecticut.
Kluger J; Department of Biomedical Engineering, Yale University, New Haven, Connecticut.
Park J; Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Jacoby DL; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, Connecticut.
Qyang Y; Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Campbell SG; Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.

JACC Basic Transl Sci ; 4(4): 495-505, 2019 Aug.

Article en En | MEDLINE | ID: mdl-31468004

Palabras clave

CM, cardiomyocyte; ECM, extracellular matrix; EHT, engineered heart tissue; H&E, hematoxylin and eosin; HCM, hypertrophic cardiomyopathy; MTR, Masson trichrome; MUT, minipig carrying MYH7 R403Q mutation; MYH7 mutation; RT50, time from peak tension to 50% relaxation; SR, Sirius red; TTP, time to peak tension; WT, wild-type; cDNA, complementary deoxyribonucleic acid; diastolic dysfunction; engineered heart tissue; fibrosis; hypertrophic cardiomyopathy; iPSC, induced pluripotent stem cell; iPSC-derived cardiomyocyte

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos

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