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Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes.
Béliveau, François; Tarkar, Aarti; Dion, Sébastien P; Désilets, Antoine; Ghinet, Mariana Gabriela; Boudreault, Pierre-Luc; St-Georges, Catherine; Marsault, Éric; Paone, Daniel; Collins, Jon; Macphee, Colin H; Campobasso, Nino; Groy, Arthur; Cottom, Josh; Ouellette, Michael; Pope, Andrew J; Leduc, Richard.
Afiliación
  • Béliveau F; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12(e) Avenue Nord, Sherbrooke, QC J1H 5N4, Canada; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.
  • Tarkar A; Discovery Partnerships with Academia, GlaxoSmithKline, Collegeville, Philadelphia, PA 19426-0989, USA.
  • Dion SP; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12(e) Avenue Nord, Sherbrooke, QC J1H 5N4, Canada; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.
  • Désilets A; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12(e) Avenue Nord, Sherbrooke, QC J1H 5N4, Canada; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.
  • Ghinet MG; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12(e) Avenue Nord, Sherbrooke, QC J1H 5N4, Canada; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.
  • Boudreault PL; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12(e) Avenue Nord, Sherbrooke, QC J1H 5N4, Canada; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.
  • St-Georges C; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12(e) Avenue Nord, Sherbrooke, QC J1H 5N4, Canada; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.
  • Marsault É; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12(e) Avenue Nord, Sherbrooke, QC J1H 5N4, Canada; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.
  • Paone D; Discovery Partnerships with Academia, GlaxoSmithKline, Collegeville, Philadelphia, PA 19426-0989, USA.
  • Collins J; Discovery Partnerships with Academia, GlaxoSmithKline, Collegeville, Philadelphia, PA 19426-0989, USA.
  • Macphee CH; Discovery Partnerships with Academia, GlaxoSmithKline, Collegeville, Philadelphia, PA 19426-0989, USA.
  • Campobasso N; Platform Technology & Science, GlaxoSmithKline, Collegeville, Philadelphia, PA 19426-0989, USA.
  • Groy A; Platform Technology & Science, GlaxoSmithKline, Collegeville, Philadelphia, PA 19426-0989, USA.
  • Cottom J; Platform Technology & Science, GlaxoSmithKline, Collegeville, Philadelphia, PA 19426-0989, USA.
  • Ouellette M; Platform Technology & Science, GlaxoSmithKline, Collegeville, Philadelphia, PA 19426-0989, USA.
  • Pope AJ; Discovery Partnerships with Academia, GlaxoSmithKline, Collegeville, Philadelphia, PA 19426-0989, USA.
  • Leduc R; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12(e) Avenue Nord, Sherbrooke, QC J1H 5N4, Canada; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada. Electronic address: richard.leduc@usherbrooke.
Cell Chem Biol ; 26(11): 1559-1572.e9, 2019 11 21.
Article en En | MEDLINE | ID: mdl-31543462
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Serina Proteinasa / Evaluación Preclínica de Medicamentos / Hepcidinas / Proteínas de la Membrana Límite: Humans Idioma: En Revista: Cell Chem Biol Año: 2019 Tipo del documento: Article País de afiliación: Canadá
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Serina Proteinasa / Evaluación Preclínica de Medicamentos / Hepcidinas / Proteínas de la Membrana Límite: Humans Idioma: En Revista: Cell Chem Biol Año: 2019 Tipo del documento: Article País de afiliación: Canadá