Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a <i>Drosophila</i> model of Parkinson's disease.

Imai, Yuzuru; Inoshita, Tsuyoshi; Meng, Hongrui; Shiba-Fukushima, Kahori; Hara, Kiyotaka Y; Sawamura, Naoya; Hattori, Nobutaka

Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson's disease.

Imai, Yuzuru; Inoshita, Tsuyoshi; Meng, Hongrui; Shiba-Fukushima, Kahori; Hara, Kiyotaka Y; Sawamura, Naoya; Hattori, Nobutaka.

Afiliación

Imai Y; 1Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, 113-8421 Japan.
Inoshita T; 2Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, 113-8421 Japan.
Meng H; 3Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable Disease, Juntendo University Graduate School of Medicine, Tokyo, 113-8421 Japan.
Shiba-Fukushima K; 4Department of Neurodegenerative and Demented Disorders, Juntendo University Graduate School of Medicine, Tokyo, 113-8421 Japan.
Hara KY; 3Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable Disease, Juntendo University Graduate School of Medicine, Tokyo, 113-8421 Japan.
Sawamura N; 5Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, 422-8526 Japan.
Hattori N; 6Research Organization for Nano & Life Innovation, Waseda University, Tokyo, 162-8480 Japan.

Commun Biol ; 2: 424, 2019.

Article en En | MEDLINE | ID: mdl-31799427

Asunto(s)

Luz; Mitocondrias/metabolismo; Mitocondrias/efectos de la radiación; Enfermedades Mitocondriales/etiología; Enfermedades Mitocondriales/metabolismo; Actividad Motora; Enfermedad de Parkinson/etiología; Enfermedad de Parkinson/metabolismo; Protones; Animales; Biomarcadores; Modelos Animales de Enfermedad; Susceptibilidad a Enfermedades; Neuronas Dopaminérgicas/metabolismo; Drosophila; Modelos Biológicos; Estrés Oxidativo; Especies Reactivas de Oxígeno/metabolismo; alfa-Sinucleína/metabolismo

Palabras clave

Cell death in the nervous system; Energy metabolism; Gene expression; Optogenetics; Parkinson's disease

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Protones / Enfermedades Mitocondriales / Luz / Mitocondrias / Actividad Motora Límite: Animals Idioma: En Revista: Commun Biol Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido

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