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Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy.
Ogata, Hidenori; Isobe, Noriko; Zhang, Xu; Yamasaki, Ryo; Fujii, Takayuki; Machida, Akira; Morimoto, Nobutoshi; Kaida, Kenichi; Masuda, Teruaki; Ando, Yukio; Kuwahara, Motoi; Kusunoki, Susumu; Nakamura, Yuri; Matsushita, Takuya; Kira, Jun-Ichi.
Afiliación
  • Ogata H; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: hidenori@neuro.med.kyushu-u.ac.jp.
  • Isobe N; Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: kuroki@neuro.med.kyushu-u.ac.jp.
  • Zhang X; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: shu-@neuro.med.kyushu-u.ac.jp.
  • Yamasaki R; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: ryoya@neuro.med.kyushu-u.ac.jp.
  • Fujii T; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: takayuki@neuro.med.kyushu-u.ac.jp.
  • Machida A; Department of Neurology, Tsuchiura Kyodo General Hospital, Ibaraki 300-0028, Japan. Electronic address: akinuro@tmd.ac.jp.
  • Morimoto N; Department of Neurology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, Japan.
  • Kaida K; Department of Neurology, Anti-aging and Vascular Medicine, National Defense Medical College, Saitama 359-8513, Japan. Electronic address: adiak901@ndmc.ac.jp.
  • Masuda T; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan. Electronic address: tmasu93@kuh.kumamoto-u.ac.jp.
  • Ando Y; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan. Electronic address: andoy709@kumamoto-u.ac.jp.
  • Kuwahara M; Department of Neurology, School of Medicine, Kindai University, Osaka, 589-8511, Japan. Electronic address: kuwahara@med.kindai.ac.jp.
  • Kusunoki S; Department of Neurology, School of Medicine, Kindai University, Osaka, 589-8511, Japan. Electronic address: kusunoki-tky@umin.ac.jp.
  • Nakamura Y; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: nakayuri@neuro.med.kyushu-u.ac.jp.
  • Matsushita T; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: matusita@neuro.med.kyushu-u.ac.jp.
  • Kira JI; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: kira@neuro.med.kyushu-u.ac.jp.
J Neuroimmunol ; 339: 577139, 2020 02 15.
Article en En | MEDLINE | ID: mdl-31864140
ABSTRACT
To clarify the immunogenetic background of patients with immunoglobulin G (IgG)4 anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP), we genotyped the extended human leukocyte antigen (HLA) haplotypes in 22 Japanese patients with this disorder and compared them with those of healthy Japanese controls. All IgG4 anti-NF155 antibody-positive CIDP patients exclusively carried either HLA-DRB1*1501-DRB5*0101-DQA1*0102-DQB1*0602 or -(A*2402)-B*5201-C*1202-DRB1*1502-DRB5*0102-DQA1*0103-DQB1*0601, resulting in significantly increased HLA-DRB1*15, -DRB1*1501, -DQB1*0601/0602, -DQB1*0602, and -DRB1*1501-DQB1*0602 frequencies compared with healthy Japanese controls. These findings indicate the involvement of specific HLA class II molecules in the pathomechanisms of IgG4 anti-NF155 antibody-positive CIDP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Haplotipos / Inmunoglobulina G / Moléculas de Adhesión Celular / Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante / Antígenos HLA / Factores de Crecimiento Nervioso Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neuroimmunol Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Haplotipos / Inmunoglobulina G / Moléculas de Adhesión Celular / Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante / Antígenos HLA / Factores de Crecimiento Nervioso Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neuroimmunol Año: 2020 Tipo del documento: Article