Induced production of a new polyketide in Penicillium sp. HS-11 by chemical epigenetic manipulation.
Nat Prod Res
; 35(20): 3446-3451, 2021 Oct.
Article
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| MEDLINE
| ID: mdl-31899961
ABSTRACT
Chemical investigation into the culture broth of the plant endophyte Penicillium sp. HS-11 in the modified Martin's medium supplemented with subemylanilide hydroxamic acid (SAHA), a well-known histone deacetylase (HDACs) inhibitor, led to the isolation and identification of two induced products 4-epipenicillone B (1) and (R)-(+)-chrysogine (2). 4-epipenicillone B (1) was obtained as a new compound whose structure was elucidated by comprehensive spectroscopic methods including 1 D/2D NMR, HRESMS, and quantum chemistry calculations including DFT GIAO 13C NMR and ECD calculation. Acquisition of 4-epipenicillone B (1) enriched the chemical diversities of fungal natural products possessing a tricyclo [5.3.1.03,8] undecane skeleton. The cytotoxic activity of 1 was also evaluated.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Penicillium
/
Policétidos
Idioma:
En
Revista:
Nat Prod Res
Año:
2021
Tipo del documento:
Article