Age- and sex-dependent differences in extracellular matrix metabolism associate with cardiac functional and structural changes.

Grilo, Gabriel A; Shaver, Patti R; Stoffel, Hamilton J; Morrow, Caleb Anthony; Johnson, Octavious T; Iyer, Rugmani P; de Castro Brás, Lisandra E

Grilo, Gabriel A; Shaver, Patti R; Stoffel, Hamilton J; Morrow, Caleb Anthony; Johnson, Octavious T; Iyer, Rugmani P; de Castro Brás, Lisandra E.

Afiliación

Grilo GA; Department of Physiology, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America.
Shaver PR; Department of Physiology, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America.
Stoffel HJ; Department of Physiology, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America.
Morrow CA; Department of Physiology, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America.
Johnson OT; Department of Physiology, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America.
Iyer RP; Department of Physiology, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America.
de Castro Brás LE; Department of Physiology, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America; Department of Cardiovascular Sciences, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States of America. Electronic address: decastr

J Mol Cell Cardiol ; 139: 62-74, 2020 02.

Article en En | MEDLINE | ID: mdl-31978395

Asunto(s)

Matriz Extracelular/metabolismo; Corazón/fisiopatología; Caracteres Sexuales; Animales; Peso Corporal; Cardiomegalia/metabolismo; Cardiomegalia/patología; Cardiomegalia/fisiopatología; Colágeno/metabolismo; Electrocardiografía; Femenino; Corazón/diagnóstico por imagen; Ventrículos Cardíacos/patología; Ventrículos Cardíacos/fisiopatología; Homeostasis; Modelos Lineales; Masculino; Ratones Endogámicos C57BL; Contracción Miocárdica; Miocitos Cardíacos/metabolismo; Miocitos Cardíacos/patología; Proteoglicanos/metabolismo; Transducción de Señal; Factor de Crecimiento Transformador beta/metabolismo; Remodelación Ventricular

Palabras clave

Aging; Cardiac dysfunction; Collagen metabolism; Sex differences; Strain analysis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caracteres Sexuales / Matriz Extracelular / Corazón Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Mol Cell Cardiol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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