Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPAR&#945; Agonists as Leads for Retinal Disorders.

Dou, Xiaozheng; Nath, Dinesh; Shin, Henry; Nurmemmedov, Elmar; Bourne, Philip C; Ma, Jian-Xing; Duerfeldt, Adam S

Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders.

Dou, Xiaozheng; Nath, Dinesh; Shin, Henry; Nurmemmedov, Elmar; Bourne, Philip C; Ma, Jian-Xing; Duerfeldt, Adam S.

Afiliación

Dou X; Institute for Natural Products Applications and Research Technologies, University of Oklahoma, 101 Stephenson Parkway, Stephenson Life Sciences Research Center, Norman, Oklahoma 73019, United States.
Nath D; Department of Chemistry & Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Stephenson Life Sciences Research Center, Norman, Oklahoma 73019, United States.
Shin H; Institute for Natural Products Applications and Research Technologies, University of Oklahoma, 101 Stephenson Parkway, Stephenson Life Sciences Research Center, Norman, Oklahoma 73019, United States.
Nurmemmedov E; Department of Chemistry & Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Stephenson Life Sciences Research Center, Norman, Oklahoma 73019, United States.
Bourne PC; Department of Physiology, University of Oklahoma Health Sciences Center, 941 Stanton L. Young Boulevard, Oklahoma City, Oklahoma 73104, United States.
Ma JX; John Wayne Cancer Institute & Pacific Neuroscience Institute at Providence Saint John's Health Center, 2200 Santa Monica Boulevard, Santa Monica, California 90404, United States.
Duerfeldt AS; Department of Chemistry & Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Stephenson Life Sciences Research Center, Norman, Oklahoma 73019, United States.

J Med Chem ; 63(6): 2854-2876, 2020 03 26.

Article en En | MEDLINE | ID: mdl-32096640

Asunto(s)

Bencilaminas/química; Bencilaminas/farmacología; Retinopatía Diabética/tratamiento farmacológico; PPAR alfa/agonistas; Animales; Bencilaminas/farmacocinética; Bencilaminas/uso terapéutico; Permeabilidad Capilar/efectos de los fármacos; Línea Celular; Retinopatía Diabética/inducido químicamente; Retinopatía Diabética/metabolismo; Modelos Animales de Enfermedad; Diseño de Fármacos; Descubrimiento de Drogas; Humanos; PPAR alfa/metabolismo; Ratas; Enfermedades de la Retina/tratamiento farmacológico; Enfermedades de la Retina/metabolismo; Estreptozocina

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bencilaminas / PPAR alfa / Retinopatía Diabética Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google