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The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer.
Luker, Andrea J; Graham, Laura J; Smith, Timothy M; Camarena, Carmen; Zellner, Matt P; Gilmer, Jamie-Jean S; Damle, Sheela R; Conrad, Daniel H; Bear, Harry D; Martin, Rebecca K.
Afiliación
  • Luker AJ; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA.
  • Graham LJ; Massey Cancer Center, VCU, Box 980678, Richmond, VA, 23298, USA.
  • Smith TM; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA.
  • Camarena C; Massey Cancer Center, VCU, Box 980678, Richmond, VA, 23298, USA.
  • Zellner MP; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA.
  • Gilmer JS; Massey Cancer Center, VCU, Box 980678, Richmond, VA, 23298, USA.
  • Damle SR; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA.
  • Conrad DH; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA.
  • Bear HD; Department of Biology, College of Humanities and Sciences, VCU, Richmond, VA, USA.
  • Martin RK; Department of Microbiology and Immunology, School of Medicine, VCU, Box 980678, Richmond, VA, 23298, USA.
BMC Immunol ; 21(1): 8, 2020 02 27.
Article en En | MEDLINE | ID: mdl-32106810
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azacitidina / Neoplasias de la Mama / Linfocitos T Citotóxicos / Inmunoterapia Adoptiva / Células Supresoras de Origen Mieloide / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: BMC Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azacitidina / Neoplasias de la Mama / Linfocitos T Citotóxicos / Inmunoterapia Adoptiva / Células Supresoras de Origen Mieloide / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: BMC Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos