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Amyloid-ß42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease.
Kwak, Sang Su; Washicosky, Kevin J; Brand, Emma; von Maydell, Djuna; Aronson, Jenna; Kim, Susan; Capen, Diane E; Cetinbas, Murat; Sadreyev, Ruslan; Ning, Shen; Bylykbashi, Enjana; Xia, Weiming; Wagner, Steven L; Choi, Se Hoon; Tanzi, Rudolph E; Kim, Doo Yeon.
Afiliación
  • Kwak SS; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
  • Washicosky KJ; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
  • Brand E; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
  • von Maydell D; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
  • Aronson J; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
  • Kim S; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Capen DE; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
  • Cetinbas M; Center for Systems Biology and Program in Membrane Biology, Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
  • Sadreyev R; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Ning S; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Bylykbashi E; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
  • Xia W; Graduate Program for Neuroscience, Boston University School of Medicine, Boston, MA, 02118, USA.
  • Wagner SL; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
  • Choi SH; Geriatric Research Education and Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, 01730, USA.
  • Tanzi RE; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, 02118, USA.
  • Kim DY; Department of Neurosciences, University of California, San Diego, La Jolla, CA, 92093, USA.
Nat Commun ; 11(1): 1377, 2020 03 13.
Article en En | MEDLINE | ID: mdl-32170138
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Péptidos beta-Amiloides / Técnicas de Cultivo de Célula / Enfermedad de Alzheimer / Neuronas Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Péptidos beta-Amiloides / Técnicas de Cultivo de Célula / Enfermedad de Alzheimer / Neuronas Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido