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Visible-Light-Promoted Selenylative Spirocyclization of Indolyl-ynones toward the Formation of 3-Selenospiroindolenine Anticancer Agents.
Zhou, Xiu-Jie; Liu, Hao-Yang; Mo, Zu-Yu; Ma, Xian-Li; Chen, Yan-Yan; Tang, Hai-Tao; Pan, Ying-Ming; Xu, Yan-Li.
Afiliación
  • Zhou XJ; Pharmacy School, Guilin Medical University, 541004, People's Republic of China, Guilin.
  • Liu HY; Pharmacy School, Guilin Medical University, 541004, People's Republic of China, Guilin.
  • Mo ZY; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, 541004, People's Republic of China, Guilin.
  • Ma XL; Pharmacy School, Guilin Medical University, 541004, People's Republic of China, Guilin.
  • Chen YY; Pharmacy School, Guilin Medical University, 541004, People's Republic of China, Guilin.
  • Tang HT; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, 541004, People's Republic of China, Guilin.
  • Pan YM; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, 541004, People's Republic of China, Guilin.
  • Xu YL; Pharmacy School, Guilin Medical University, 541004, People's Republic of China, Guilin.
Chem Asian J ; 15(10): 1536-1539, 2020 May 15.
Article en En | MEDLINE | ID: mdl-32207240
A metal-free and efficient visible-light-induced spirocyclization of indolyl-ynones with diselenides at room temperature under air atmosphere to prepare 3-selenospiroindolenines in moderate to good yields has been developed. The resulting products were tested for in vitro anticancer activity by MTT assay, and compounds 3 c and 3 e showed potent cancer cell-growth inhibition activities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Espiro / Compuestos de Organoselenio / Aldehídos / Indoles / Luz / Antineoplásicos Límite: Humans Idioma: En Revista: Chem Asian J Año: 2020 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Espiro / Compuestos de Organoselenio / Aldehídos / Indoles / Luz / Antineoplásicos Límite: Humans Idioma: En Revista: Chem Asian J Año: 2020 Tipo del documento: Article Pais de publicación: Alemania