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A six-weekly dosing schedule for pembrolizumab in patients with cancer based on evaluation using modelling and simulation.
Lala, Mallika; Li, Tommy Ruosi; de Alwis, Dinesh P; Sinha, Vikram; Mayawala, Kapil; Yamamoto, Noboru; Siu, Lillian L; Chartash, Elliot; Aboshady, Hesham; Jain, Lokesh.
Afiliación
  • Lala M; Quantitative Pharmacology and Pharmacometrics; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Li TR; Quantitative Pharmacology and Pharmacometrics; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, NJ, USA.
  • de Alwis DP; Quantitative Pharmacology and Pharmacometrics; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Sinha V; Quantitative Pharmacology and Pharmacometrics; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Mayawala K; Quantitative Pharmacology and Pharmacometrics; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Yamamoto N; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.
  • Siu LL; University of Toronto, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
  • Chartash E; Oncology Early Development, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Aboshady H; Clinical Safety and Risk Management, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Jain L; Quantitative Pharmacology and Pharmacometrics; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Kenilworth, NJ, USA. Electronic address: lokesh_jain@merck.com.
Eur J Cancer ; 131: 68-75, 2020 05.
Article en En | MEDLINE | ID: mdl-32305010
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anticuerpos Monoclonales Humanizados / Antineoplásicos Inmunológicos / Modelos Biológicos / Neoplasias Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Cancer Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anticuerpos Monoclonales Humanizados / Antineoplásicos Inmunológicos / Modelos Biológicos / Neoplasias Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Cancer Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido