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Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial.
Sharman, Jeff P; Egyed, Miklos; Jurczak, Wojciech; Skarbnik, Alan; Pagel, John M; Flinn, Ian W; Kamdar, Manali; Munir, Talha; Walewska, Renata; Corbett, Gillian; Fogliatto, Laura Maria; Herishanu, Yair; Banerji, Versha; Coutre, Steven; Follows, George; Walker, Patricia; Karlsson, Karin; Ghia, Paolo; Janssens, Ann; Cymbalista, Florence; Woyach, Jennifer A; Salles, Gilles; Wierda, William G; Izumi, Raquel; Munugalavadla, Veerendra; Patel, Priti; Wang, Min Hui; Wong, Sofia; Byrd, John C.
Afiliación
  • Sharman JP; Willamette Valley Cancer Institute/US Oncology, Eugene, OR, USA.
  • Egyed M; Department of Hematology, Somogy County Mór Kaposi General Hospital, Kaposvár, Hungary.
  • Jurczak W; Maria Sklodowska-Curie National Institute of Oncology, Kraków, Poland.
  • Skarbnik A; Department of Medicine, John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA; Lymphoproliferative Disorders Program, Novant Health Cancer Institute, Charlotte NC, USA.
  • Pagel JM; Swedish Cancer Institute, Center for Blood Disorders and Stem Cell Transplantation, Seattle, WA, USA.
  • Flinn IW; Sarah Cannon Research Institute, Tennessee Oncology Nashville, Nashville, TN, USA.
  • Kamdar M; Division of Hematology, Hematologic Malignancies and Stem Cell Transplantation, University of Colorado Cancer Center, Aurora, CO, USA.
  • Munir T; Haematological Malignancy Diagnostic Service (HMDS), St James's Institute of Oncology, Leeds, UK.
  • Walewska R; Molecular Pathology, Royal Bournemouth Hospital, Bournemouth, UK.
  • Corbett G; Department of Medicine, Tauranga Hospital, Tauranga, New Zealand.
  • Fogliatto LM; Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
  • Herishanu Y; Department of Hematology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Banerji V; Departments of Internal Medicine, Biochemistry & Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Research Institute in Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB, Canada.
  • Coutre S; Stanford University School of Medicine, Stanford, CA, USA.
  • Follows G; Department of Haematology, Addenbrooke's Hospital NHS Trust, Cambridge, UK.
  • Walker P; Peninsula Health, and Peninsula Private Hospital, Frankston, Victoria, Australia; Alfred Health, Melbourne, Victoria, Australia.
  • Karlsson K; Department of Haematology, Oncology and Radiophysics, Skåne University Hospital, Lund, Sweden.
  • Ghia P; Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milano, Italy.
  • Janssens A; Hematology Department, University Hospitals Leuven, Leuven, Belgium.
  • Cymbalista F; Bobigny: Hématologie, CHU Avicennes, Bobigny, France.
  • Woyach JA; The Ohio State University Comprehensive Cancer Center and Division of Hematology, Columbus, OH, USA.
  • Salles G; Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d'Hématologie Clinique, Pierre-Bénite, France.
  • Wierda WG; Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX, USA.
  • Izumi R; Acerta Pharma, a member of the AstraZeneca Group, South San Francisco, CA, USA.
  • Munugalavadla V; Acerta Pharma, a member of the AstraZeneca Group, South San Francisco, CA, USA.
  • Patel P; Acerta Pharma, a member of the AstraZeneca Group, South San Francisco, CA, USA.
  • Wang MH; Acerta Pharma, a member of the AstraZeneca Group, South San Francisco, CA, USA.
  • Wong S; Acerta Pharma, a member of the AstraZeneca Group, South San Francisco, CA, USA.
  • Byrd JC; The Ohio State University Comprehensive Cancer Center and Division of Hematology, Columbus, OH, USA. Electronic address: john.byrd@osumc.edu.
Lancet ; 395(10232): 1278-1291, 2020 04 18.
Article en En | MEDLINE | ID: mdl-32305093
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazinas / Benzamidas / Leucemia Linfocítica Crónica de Células B / Clorambucilo / Anticuerpos Monoclonales Humanizados / Agammaglobulinemia Tirosina Quinasa Tipo de estudio: Clinical_trials Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazinas / Benzamidas / Leucemia Linfocítica Crónica de Células B / Clorambucilo / Anticuerpos Monoclonales Humanizados / Agammaglobulinemia Tirosina Quinasa Tipo de estudio: Clinical_trials Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido