The reorganization of conformations, stability and aggregation of serum albumin isomers through the interaction of glycopeptide antibiotic teicoplanin: A thermodynamic and spectroscopy study.

Muthu, Shivani A; Jadav, Helly Chetan; Srivastava, Sadhavi; Pissurlenkar, Raghuvir R S; Ahmad, Basir

Muthu, Shivani A; Jadav, Helly Chetan; Srivastava, Sadhavi; Pissurlenkar, Raghuvir R S; Ahmad, Basir.

Afiliación

Muthu SA; Protein Assembly Laboratory (PAL), JH-Institute of Molecular Medicine, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India.
Jadav HC; School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences, University of Mumbai, Vidyanagari Campus, Mumbai 400098, India.
Srivastava S; School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences, University of Mumbai, Vidyanagari Campus, Mumbai 400098, India; Department of Biotechnology, Central University of South Bihar, Gaya 824236, India.
Pissurlenkar RRS; Department of Pharmaceutical and Medicinal Chemistry, Goa College of Pharmacy, 18th June Road, Panaji, Goa 403001, India.
Ahmad B; Protein Assembly Laboratory (PAL), JH-Institute of Molecular Medicine, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India. Electronic address: bashirahmad_sch@jamiahamdard.ac.in.

Int J Biol Macromol ; 163: 66-78, 2020 Nov 15.

Article en En | MEDLINE | ID: mdl-32615213

Asunto(s)

Albúmina Sérica Bovina/química; Albúmina Sérica Bovina/metabolismo; Teicoplanina/química; Teicoplanina/metabolismo; Amiloidosis/tratamiento farmacológico; Animales; Sitios de Unión; Calorimetría; Dicroismo Circular; Concentración de Iones de Hidrógeno; Cinética; Modelos Moleculares; Simulación del Acoplamiento Molecular; Agregado de Proteínas; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Estabilidad Proteica; Estructura Secundaria de Proteína; Estructura Terciaria de Proteína; Espectrometría de Fluorescencia/métodos; Temperatura; Termodinámica

Palabras clave

Biophysical chemistry; Drug repurposing; Drug-protein interaction; Isothermal titration calorimetry; Protein aggregation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Albúmina Sérica Bovina / Teicoplanina Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2020 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos

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