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The inorganic polymer, polyphosphate, blocks binding of SARS-CoV-2 spike protein to ACE2 receptor at physiological concentrations.
Neufurth, Meik; Wang, Xiaohong; Tolba, Emad; Lieberwirth, Ingo; Wang, Shunfeng; Schröder, Heinz C; Müller, Werner E G.
Afiliación
  • Neufurth M; ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128 Mainz, Germany.
  • Wang X; ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128 Mainz, Germany. Electronic address: wang013@uni-mainz.de.
  • Tolba E; ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128 Mainz, Germany.
  • Lieberwirth I; Max Planck Institute for Polymer Research, Ackermannweg 10, D-55128 Mainz, Germany.
  • Wang S; ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128 Mainz, Germany.
  • Schröder HC; ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128 Mainz, Germany.
  • Müller WEG; ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128 Mainz, Germany. Electronic address: wmueller@uni-mainz.de.
Biochem Pharmacol ; 182: 114215, 2020 12.
Article en En | MEDLINE | ID: mdl-32905794
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Polifosfatos / Glicoproteína de la Espiga del Coronavirus / Receptores de Coronavirus / Enzima Convertidora de Angiotensina 2 Límite: Humans Idioma: En Revista: Biochem Pharmacol Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Polifosfatos / Glicoproteína de la Espiga del Coronavirus / Receptores de Coronavirus / Enzima Convertidora de Angiotensina 2 Límite: Humans Idioma: En Revista: Biochem Pharmacol Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido