Molecular heterogeneity of anti-PD-1/PD-L1 immunotherapy efficacy is correlated with tumor immune microenvironment in East Asian patients with non-small cell lung cancer.

Jin, Runsen; Liu, Chengming; Zheng, Sufei; Wang, Xinfeng; Feng, Xiaoli; Li, Hecheng; Sun, Nan; He, Jie

Jin, Runsen; Liu, Chengming; Zheng, Sufei; Wang, Xinfeng; Feng, Xiaoli; Li, Hecheng; Sun, Nan; He, Jie.

Afiliación

Jin R; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Liu C; Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Zheng S; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Wang X; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Feng X; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Li H; Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Sun N; Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
He J; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Cancer Biol Med ; 17(3): 768-781, 2020 08 15.

Article en En | MEDLINE | ID: mdl-32944405

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas/genética; Neoplasias Pulmonares/genética; Mutación; Microambiente Tumoral/genética; Quinasa de Linfoma Anaplásico/genética; Antineoplásicos Inmunológicos/farmacología; Antineoplásicos Inmunológicos/uso terapéutico; Antígeno B7-H1/antagonistas & inhibidores; Linfocitos T CD4-Positivos/inmunología; Linfocitos T CD8-positivos/inmunología; Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Carcinoma de Pulmón de Células no Pequeñas/patología; Estudios de Cohortes; Receptores ErbB/genética; Femenino; Humanos; Inmunoterapia/métodos; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/patología; Linfocitos Infiltrantes de Tumor/inmunología; Masculino; Pronóstico; Receptor de Muerte Celular Programada 1/antagonistas & inhibidores

Palabras clave

East Asian; NSCLC; PD-1/PD-L1 inhibitors; immune microenvironment; oncogene mutations

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Microambiente Tumoral / Neoplasias Pulmonares / Mutación Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans / Male Idioma: En Revista: Cancer Biol Med Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: China

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