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Evaluation of 1,1-cyclopropylidene as a thioether isostere in the 4-thio-thienopyrimidine (TTP) series of antimalarials.
Barrows, Robert D; Hammill, Jared T; Tran, Michael C; Falade, Mofolusho O; Rice, Amy L; Davis, Christopher W; Emge, Thomas J; Rablen, Paul R; Kiplin Guy, R; Knapp, Spencer.
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  • Barrows RD; Department of Chemistry and Chemical Biology, Rutgers The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA.
  • Hammill JT; Department of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, 40506, 789 S Limestone, Lexington, KY 40508, USA.
  • Tran MC; Department of Chemistry and Chemical Biology, Rutgers The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA.
  • Falade MO; Department of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, 40506, 789 S Limestone, Lexington, KY 40508, USA.
  • Rice AL; Department of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, 40506, 789 S Limestone, Lexington, KY 40508, USA.
  • Davis CW; Department of Chemistry and Chemical Biology, Rutgers The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA.
  • Emge TJ; Department of Chemistry and Chemical Biology, Rutgers The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA.
  • Rablen PR; Department of Chemistry and Biochemistry, Swarthmore College, 500 College Avenue, Swarthmore, PA 19081, USA.
  • Kiplin Guy R; Department of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, 40506, 789 S Limestone, Lexington, KY 40508, USA.
  • Knapp S; Department of Chemistry and Chemical Biology, Rutgers The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA.
Bioorg Med Chem ; 28(22): 115758, 2020 11 15.
Article en En | MEDLINE | ID: mdl-33007559
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Pirimidinas / Ciclopropanos / Antimaláricos Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Pirimidinas / Ciclopropanos / Antimaláricos Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos