Hypothyroidism Induces Interleukin-1-Dependent Autophagy Mechanism as a Key Mediator of Hippocampal Neuronal Apoptosis and Cognitive Decline in Postnatal Rats.

Mishra, Juhi; Vishwakarma, Jitendra; Malik, Rafat; Gupta, Keerti; Pandey, Rukmani; Maurya, Shailendra Kumar; Garg, Asmita; Shukla, Manoj; Chattopadhyay, Naibedya; Bandyopadhyay, Sanghamitra

Mishra, Juhi; Vishwakarma, Jitendra; Malik, Rafat; Gupta, Keerti; Pandey, Rukmani; Maurya, Shailendra Kumar; Garg, Asmita; Shukla, Manoj; Chattopadhyay, Naibedya; Bandyopadhyay, Sanghamitra.

Afiliación

Mishra J; Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, Lucknow, Uttar Pradesh, 226001, India.
Vishwakarma J; Department of Biochemistry, Babu Banarasi Das University, Faizabad Road, Lucknow, Uttar Pradesh, India.
Malik R; Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, Lucknow, Uttar Pradesh, 226001, India.
Gupta K; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.
Pandey R; Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, Lucknow, Uttar Pradesh, 226001, India.
Maurya SK; Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, Lucknow, Uttar Pradesh, 226001, India.
Garg A; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.
Shukla M; Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, Lucknow, Uttar Pradesh, 226001, India.
Chattopadhyay N; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.
Bandyopadhyay S; Department of Psychiatry, Center for Molecular Biology and Genetics of Neurodegeneration, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Mol Neurobiol ; 58(3): 1196-1211, 2021 Mar.

Article en En | MEDLINE | ID: mdl-33106949

Asunto(s)

Apoptosis; Autofagia; Disfunción Cognitiva/etiología; Hipocampo/patología; Hipotiroidismo/complicaciones; Hipotiroidismo/patología; Interleucina-1/metabolismo; Neuronas/patología; Animales; Animales Recién Nacidos; Apoptosis/efectos de los fármacos; Autofagia/efectos de los fármacos; Disfunción Cognitiva/patología; Disfunción Cognitiva/fisiopatología; Hipocampo/metabolismo; Hipocampo/fisiopatología; Hipotiroidismo/sangre; Hipotiroidismo/fisiopatología; Inflamación/patología; Memoria/efectos de los fármacos; Metimazol/farmacología; Microglía/efectos de los fármacos; Microglía/patología; Proteínas Asociadas a Microtúbulos/metabolismo; Modelos Biológicos; Neuronas/efectos de los fármacos; Neuronas/metabolismo; Fosforilación/efectos de los fármacos; Ratas Wistar; Serina-Treonina Quinasas TOR/metabolismo; Tiroxina/sangre; Triyodotironina/sangre

Palabras clave

Autophagy; Hippocampus; Inflammation; Memory loss; Thyroid hormone deficiency

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Interleucina-1 / Apoptosis / Disfunción Cognitiva / Hipocampo / Hipotiroidismo / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Neurobiol Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos

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