Your browser doesn't support javascript.
loading
4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders.
Borsari, Chiara; Keles, Erhan; Rageot, Denise; Treyer, Andrea; Bohnacker, Thomas; Bissegger, Lukas; De Pascale, Martina; Melone, Anna; Sriramaratnam, Rohitha; Beaufils, Florent; Hamburger, Matthias; Hebeisen, Paul; Löscher, Wolfgang; Fabbro, Doriano; Hillmann, Petra; Wymann, Matthias P.
Afiliación
  • Borsari C; Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Keles E; Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Rageot D; Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Treyer A; Pharmaceutical Biology, Pharmacenter, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
  • Bohnacker T; Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Bissegger L; Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • De Pascale M; Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Melone A; Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Sriramaratnam R; Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
  • Beaufils F; PIQUR Therapeutics AG, Hochbergerstrasse 60, 4057 Basel, Switzerland.
  • Hamburger M; Pharmaceutical Biology, Pharmacenter, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
  • Hebeisen P; PIQUR Therapeutics AG, Hochbergerstrasse 60, 4057 Basel, Switzerland.
  • Löscher W; Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, 30559 Hannover, Germany.
  • Fabbro D; Center for Systems Neuroscience, University of Veterinary Medicine, 30559 Hannover, Germany.
  • Hillmann P; PIQUR Therapeutics AG, Hochbergerstrasse 60, 4057 Basel, Switzerland.
  • Wymann MP; PIQUR Therapeutics AG, Hochbergerstrasse 60, 4057 Basel, Switzerland.
J Med Chem ; 63(22): 13595-13617, 2020 11 25.
Article en En | MEDLINE | ID: mdl-33166139
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Morfolinas / Serina-Treonina Quinasas TOR / Enfermedades del Sistema Nervioso Límite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Morfolinas / Serina-Treonina Quinasas TOR / Enfermedades del Sistema Nervioso Límite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Suiza