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mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote KrasG12D-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis.
Zhao, Yamin; Schoeps, Benjamin; Yao, Dianbo; Zhang, Zhiheng; Schuck, Kathleen; Tissen, Vivien; Jäger, Carsten; Schlitter, Anna Melissa; van der Kammen, Rob; Ludwig, Christina; D'Haese, Jan G; Raulefs, Susanne; Maeritz, Nadja; Shen, Shanshan; Zou, Xiaoping; Krüger, Achim; Kleeff, Jörg; Michalski, Christoph W; Friess, Helmut; Innocenti, Metello; Kong, Bo.
Afiliación
  • Zhao Y; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
  • Schoeps B; Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Yao D; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
  • Zhang Z; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
  • Schuck K; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
  • Tissen V; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
  • Jäger C; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
  • Schlitter AM; Institute of Pathology, Technical University of Munich, Munich, Germany.
  • van der Kammen R; Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Ludwig C; Bavarian Center for Biomolecular Mass Spectrometry, Technical University of Munich, Freising, Germany.
  • D'Haese JG; Department of General, Visceral, and Transplantation, Ludwig Maximilians University, Munich, Germany.
  • Raulefs S; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
  • Maeritz N; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
  • Shen S; Department of Gastroenterology, the Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China.
  • Zou X; Department of Gastroenterology, the Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China.
  • Krüger A; Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Kleeff J; Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Germany.
  • Michalski CW; Department of General Surgery, University of Ulm, Ulm, Germany.
  • Friess H; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
  • Innocenti M; Heidelberg University Biochemistry Center, Heidelberg University, Heidelberg, Germany.
  • Kong B; Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany; Department of Gastroenterology, the Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China; German Cancer Consortium at the partner site Munich, Munich,
Gastroenterology ; 160(5): 1755-1770.e17, 2021 04.
Article en En | MEDLINE | ID: mdl-33388318
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conductos Pancreáticos / Neoplasias Pancreáticas / Transformación Celular Neoplásica / Proteínas Proto-Oncogénicas p21(ras) / Carcinoma Ductal Pancreático / Complejo 2-3 Proteico Relacionado con la Actina / Células Acinares / Diana Mecanicista del Complejo 1 de la Rapamicina / Diana Mecanicista del Complejo 2 de la Rapamicina / Mutación Límite: Animals / Humans Idioma: En Revista: Gastroenterology Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conductos Pancreáticos / Neoplasias Pancreáticas / Transformación Celular Neoplásica / Proteínas Proto-Oncogénicas p21(ras) / Carcinoma Ductal Pancreático / Complejo 2-3 Proteico Relacionado con la Actina / Células Acinares / Diana Mecanicista del Complejo 1 de la Rapamicina / Diana Mecanicista del Complejo 2 de la Rapamicina / Mutación Límite: Animals / Humans Idioma: En Revista: Gastroenterology Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos