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Synthetic cyclopenta[b]indoles exhibit antineoplastic activity by targeting microtubule dynamics in acute myeloid leukemia cells.
Vicari, Hugo Passos; Lima, Keli; Gomes, Ralph da Costa; Fernandes, Daniara Cristina; da Silva, Jean Carlos Lipreri; Rodrigues Junior, Manoel Trindade; Barroso de Oliveira, Aline Silva; Dos Santos, Ricardo Nascimento; Andricopulo, Adriano Defini; Coelho, Fernando; Costa-Lotufo, Leticia Veras; Machado-Neto, João Agostinho.
Afiliación
  • Vicari HP; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, 05508-900, Brazil.
  • Lima K; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, 05508-900, Brazil.
  • Gomes RDC; Department of Organic Chemistry, Chemistry Institute, University of Campinas, Campinas, São Paulo, SP, 13083-970, Brazil.
  • Fernandes DC; Department of Organic Chemistry, Chemistry Institute, University of Campinas, Campinas, São Paulo, SP, 13083-970, Brazil; Currently at Instituto Federal de Educação Ciência e Tecnologia de São Paulo, Matão, SP, 15991-502, Brazil.
  • da Silva JCL; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, 05508-900, Brazil.
  • Rodrigues Junior MT; Department of Organic Chemistry, Chemistry Institute, University of Campinas, Campinas, São Paulo, SP, 13083-970, Brazil.
  • Barroso de Oliveira AS; Department of Organic Chemistry, Chemistry Institute, University of Campinas, Campinas, São Paulo, SP, 13083-970, Brazil.
  • Dos Santos RN; Physics Institute of São Carlos, University of São Paulo, São Carlos, SP, 13565-905, Brazil.
  • Andricopulo AD; Physics Institute of São Carlos, University of São Paulo, São Carlos, SP, 13565-905, Brazil.
  • Coelho F; Department of Organic Chemistry, Chemistry Institute, University of Campinas, Campinas, São Paulo, SP, 13083-970, Brazil.
  • Costa-Lotufo LV; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, 05508-900, Brazil.
  • Machado-Neto JA; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, 05508-900, Brazil. Electronic address: jamachadoneto@usp.br.
Eur J Pharmacol ; 894: 173853, 2021 Mar 05.
Article en En | MEDLINE | ID: mdl-33422507
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Promielocítica Aguda / Ciclopentanos / Indoles / Microtúbulos / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Promielocítica Aguda / Ciclopentanos / Indoles / Microtúbulos / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos