Nosiheptide analogues as potential antibacterial agents via dehydroalanine region modifications: Semi-synthesis, antimicrobial activity and molecular docking study.

Fan, Yafei; Chen, Hangfei; Mu, Ning; Wang, Wengui; Zhu, Kongkai; Ruan, Zhi; Wang, Shoufeng

Fan, Yafei; Chen, Hangfei; Mu, Ning; Wang, Wengui; Zhu, Kongkai; Ruan, Zhi; Wang, Shoufeng.

Afiliación

Fan Y; Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China.
Chen H; Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Mu N; Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China.
Wang W; Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China.
Zhu K; School of Biological Science and Technology, University of Jinan, Jinan 250022, China; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. Electronic address: bio_zhuk
Ruan Z; Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China. Electronic address: r_z@zju.edu.cn.
Wang S; Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China. Electronic address: chm_wangsf@ujn.edu.cn.

Bioorg Med Chem ; 31: 115970, 2021 02 01.

Article en En | MEDLINE | ID: mdl-33422909

Asunto(s)

Alanina/análogos & derivados; Antibacterianos/farmacología; Enterococcus faecium/efectos de los fármacos; Staphylococcus aureus Resistente a Meticilina/efectos de los fármacos; Simulación del Acoplamiento Molecular; Alanina/química; Alanina/farmacología; Antibacterianos/síntesis química; Antibacterianos/química; Relación Dosis-Respuesta a Droga; Farmacorresistencia Bacteriana Múltiple/efectos de los fármacos; Pruebas de Sensibilidad Microbiana; Estructura Molecular; Relación Estructura-Actividad; Tiazoles/síntesis química; Tiazoles/química; Tiazoles/farmacología

Palabras clave

Antimicrobial activity; Molecular docking; Nosiheptide analogues; Semi-synthesis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enterococcus faecium / Alanina / Staphylococcus aureus Resistente a Meticilina / Simulación del Acoplamiento Molecular / Antibacterianos Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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