PEG-GO@XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to-mesenchymal transition.

Zhang, Jialing; Yan, Liang; Wei, Peng; Zhou, Ruyi; Hua, Chaoju; Xiao, Min; Tu, Yaping; Gu, Zhanjun; Wei, Taotao

Zhang, Jialing; Yan, Liang; Wei, Peng; Zhou, Ruyi; Hua, Chaoju; Xiao, Min; Tu, Yaping; Gu, Zhanjun; Wei, Taotao.

Afiliación

Zhang J; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing, 100101, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, China.
Yan L; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, China.
Wei P; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing, 100101, China.
Zhou R; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, China.
Hua C; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing, 100101, China.
Xiao M; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing, 100101, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, China.
Tu Y; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE68178, USA.
Gu Z; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, China.
Wei T; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing, 100101, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, China. Electronic address: weitt@ibp.ac.cn.

Eur J Pharmacol ; 895: 173866, 2021 Mar 15.

Article en En | MEDLINE | ID: mdl-33454376

Asunto(s)

Antineoplásicos/farmacología; Neoplasias de la Mama/tratamiento farmacológico; Transición Epitelial-Mesenquimal/efectos de los fármacos; Neoplasias Pulmonares/prevención & control; Mitocondrias/efectos de los fármacos; Nanocompuestos; Fosforilación Oxidativa/efectos de los fármacos; Polietilenglicoles/farmacología; Citoesqueleto de Actina/efectos de los fármacos; Citoesqueleto de Actina/metabolismo; Citoesqueleto de Actina/patología; Adenosina Trifosfato/metabolismo; Animales; Neoplasias de la Mama/metabolismo; Neoplasias de la Mama/patología; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Composición de Medicamentos; Femenino; Humanos; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/secundario; Ratones Endogámicos BALB C; Ratones Desnudos; Mitocondrias/metabolismo; Mitocondrias/patología; Invasividad Neoplásica; Seudópodos/efectos de los fármacos; Seudópodos/metabolismo; Seudópodos/patología; Transducción de Señal; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Breast cancer metastasis; Energy metabolism; Epithelial-mesenchymal transition; Graphene oxide; Mitochondria; Xanthohumol

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosforilación Oxidativa / Polietilenglicoles / Neoplasias de la Mama / Nanocompuestos / Transición Epitelial-Mesenquimal / Neoplasias Pulmonares / Mitocondrias / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Eur J Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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