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Saliva viral load better correlates with clinical and immunological profiles in children with coronavirus disease 2019.
Chua, Gilbert T; Wong, Joshua S C; To, Kelvin K W; Lam, Ivan C S; Yau, Felix Y S; Chan, Wai Hung; Ho, Polly P K; Duque, Jaime S R; Yip, Cyril C Y; Ng, Anthony C K; Wong, Wilfred H S; Kwong, Joyce H Y; Leung, Kate F S; Wan, P T; Lam, Kelly; Wong, Ian C K; Kwok, Janette; Ho, Marco H K; Chan, Godfrey C F; Lau, Yu Lung; Ip, Patrick; Kwan, Mike Y W.
Afiliación
  • Chua GT; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Wong JSC; Paediatric Infectious Disease Unit, Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.
  • To KKW; Department of Microbiology, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Lam ICS; Paediatric Infectious Disease Unit, Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.
  • Yau FYS; Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong SAR, People's Republic of China.
  • Chan WH; Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong SAR, People's Republic of China.
  • Ho PPK; Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong SAR, People's Republic of China.
  • Duque JSR; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Yip CCY; Department of Microbiology, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Ng ACK; Department of Microbiology, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Wong WHS; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Kwong JHY; Haematology laboratory, Department of Pathology, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.
  • Leung KFS; Haematology laboratory, Department of Pathology, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.
  • Wan PT; Haematology laboratory, Department of Pathology, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.
  • Lam K; Haematology laboratory, Department of Pathology, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.
  • Wong ICK; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Kwok J; Research Department of Practice and Policy, UCL School of Pharmacy, University College, London, United Kingdom.
  • Ho MHK; Divison of Transplantation and Immunogenetics, Department of Pathology, Queen Mary Hospital, HKSAR, People's Republic of China.
  • Chan GCF; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Lau YL; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Ip P; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
  • Kwan MYW; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Emerg Microbes Infect ; 10(1): 235-241, 2021 Dec.
Article en En | MEDLINE | ID: mdl-33467982
BACKGROUND: Pediatric COVID-19 studies exploring the relationships between NPS and saliva viral loads, clinical and immunological profiles are lacking. METHODS: Demographics, immunological profiles, nasopharyngeal swab (NPS), and saliva samples collected on admission, and hospital length of stay (LOS) were assessed in children below 18 years with COVID-19. FINDINGS: 91 patients were included between March and August 20 20. NPS and saliva viral loads were correlated (r = 0.315, p = 0.01). Symptomatic patients had significantly higher NPS and saliva viral loads than asymptomatic patients. Serial NPS and saliva viral load measurements showed that the log10 NPS (r = -0.532, p < 0.001) and saliva (r = -0.417, p < 0.001) viral loads for all patients were inversely correlated with the days from symptom onset with statistical significance. Patients with cough, sputum, and headache had significantly higher saliva, but not NPS, viral loads. Higher saliva, but not NPS, viral loads were associated with total lymphopenia, CD3 and CD4 lymphopenia (all p < 0.05), and were inversely correlated with total lymphocyte (r = -0.43), CD3 (r = -0.55), CD4 (r = -0.60), CD8 (r = -0.41), B (r = -0.482), and NK (r = -0.416) lymphocyte counts (all p < 0.05). INTERPRETATION: Saliva viral loads on admission in children correlated better with clinical and immunological profiles than NPS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / Carga Viral / SARS-CoV-2 / COVID-19 Tipo de estudio: Diagnostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Emerg Microbes Infect Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / Carga Viral / SARS-CoV-2 / COVID-19 Tipo de estudio: Diagnostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Emerg Microbes Infect Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos